Evidence map›Paper›PMID 25943494›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2015

Genome editing technologies: defining a path to clinic.

Jacqueline Corrigan-Curay, Marina O'Reilly, Donald B Kohn, Paula M Cannon, Gang Bao, Frederic D Bushman, Dana Carroll, Toni Cathomen, J Keith Joung, David Roth and 9 more

Abstract readConference Proceedings
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed.

  1. Article
  2. Article
  3. CRISPR-Cas Genome Editing inHuman gene therapy · 2024
    Article
  4. Review
  5. Review
  6. Article
  7. Evaluation of twoMolecular therapy. Methods & clinical development · 2021
    Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Modulating gene regulation to treat genetic disorders.Nature reviews. Drug discovery · 2020
    Review
  13. Article
  14. Review
  15. Article
  16. Nucleic Acid Immunotherapeutics for Cancer.ACS applied bio materials · 2020
    Article
  17. Article
  18. Review
  19. THE GORDON WILSON LECTURE: THE ETHICS OF HUMAN GENOME EDITING.Transactions of the American Clinical and Climatological Association · 2020
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Jacqueline Corrigan-CurayNational Institutes of Health, Bethesda, Maryland, USA. Electronic address: corrigaja@nhlbi.nih.gov.
Marina O'ReillyNational Institutes of Health, Bethesda, Maryland, USA.
Donald B KohnUniversity of California, Los Angeles, Los Angeles, California, USA.
Paula M CannonKeck School of Medicine, University of Southern California, Los Angeles, California, USA.
Gang BaoGeorgia Institute of Technology, Atlanta, Georgia, USA.
Frederic D BushmanUniversity of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania, USA.
Dana CarrollUniversity of Utah, School of Medicine, Salt Lake City, Utah, USA.
Toni CathomenUniversity Medical Center Freiberg, Freiberg, Germany.
J Keith JoungMassachusetts General Hospital, Charlestown, Massachusetts; Harvard Medical School, Boston, Massachusetts, USA.
David RothUniversity of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania, USA.
Michel SadelainMemorial Sloan-Kettering Cancer Center, New York, New York, USA.
Andrew M ScharenbergSeattle Children's Research Institute and University of Washington, School of Medicine, Seattle, Washington, USA.
Christof von KalleNational Center for Tumor Diseases and German Cancer Research Center, Heidelberg, Germany.
Feng ZhangMassachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA.
Robert JambouNational Institutes of Health, Bethesda, Maryland, USA.
Eugene RosenthalNational Institutes of Health, Bethesda, Maryland, USA.
Morad HassaniNational Institutes of Health, Bethesda, Maryland, USA.
Aparna SinghNational Institutes of Health, Bethesda, Maryland, USA.
Matthew H PorteusStanford University, California, Stanford, California, USA.

Funding

Optimizing Genome Engineering with Targetable NucleasesR01GM078571 · NIGMS · UNIVERSITY OF UTAH · PI CARROLL, DANA · 2006 to 2017
$4.3M
Massively Parallel Analysis of Integration in Therapeutic Gene TransferR01AI082020 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI BUSHMAN, FREDERIC D · 2009 to 2018
$3.5M
NIAID NIH HHS R01 AI082020NIGMS NIH HHS R01 GM078571
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

GenomeAnimalsDNA Breaks, Double-StrandedDNA RepairGene RearrangementGenetic EngineeringGenomicsHumansModels, AnimalMutagenicity TestsTranslational Research, Biomedical

Identifiers

PMID25943494
PMCPMC4427885

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.