Evidence map›Paper›PMID 25943201›Full record

Observational studyThe Journal of infectious diseases2015

Herpes Simplex [corrected] Virus Type 2 Shedding From Male Circumcision Wounds in Rakai, Uganda.

Mary K Grabowski, Godfrey Kigozi, Ronald H Gray, Benjamin Armour, Jordyn Manucci, David Serwadda, Andrew D Redd, Fred Nalugoda, Eshan U Patel, Maria J Wawer and 2 more

Erratum issuedOpen access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The Journal of infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. HIV Transmission and Immunology of the Male Reproductive Tract.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026
    Review
  2. Penile Immune Activation and Risk of HIV Shedding: A Prospective Cohort Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017
    Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Mary K GrabowskiDepartment of Epidemiology, Bloomberg School of Public Health.
Godfrey KigoziRakai Health Sciences Program, Entebbe.
Ronald H GrayDepartment of Epidemiology, Bloomberg School of Public Health Rakai Health Sciences Program, Entebbe.
Benjamin ArmourDepartments of Medicine.
Jordyn ManucciDepartments of Medicine.
David SerwaddaRakai Health Sciences Program, Entebbe Institute of Public Health, Makerere University, Kampala, Uganda.
Andrew D ReddDepartments of Medicine Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Fred NalugodaRakai Health Sciences Program, Entebbe.
Eshan U PatelDivision of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Maria J WawerDepartment of Epidemiology, Bloomberg School of Public Health Rakai Health Sciences Program, Entebbe.
Thomas C QuinnDepartments of Medicine Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland Rakai Health Sciences Program, Entebbe.
Aaron A R TobianDepartment of Epidemiology, Bloomberg School of Public Health Pathology, School of Medicine, Johns Hopkins University, Baltimore Rakai Health Sciences Program, Entebbe.
Rakai Health Sciences Program · UGJohns Hopkins University · USNational Institute of Allergy and Infectious Diseases · USNational Institutes of Health · US

Funding

International Center for Excellence in Research (ICER) in Uganda: Impact of ARVsZIAAI001040 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI REYNOLDS, STEVEN · 2009 to 2025
$23.5M
International Studies of the Acquired Immune Deficiency Syndrome (AIDS)ZIAAI000361 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI REDD, ANDREW · 2009 to 2025
$15.8M
Oncogenic HPV, Mucosal Immune Response and Risk of HIV AcquisitionK23AI093152 · NIAID · JOHNS HOPKINS UNIVERSITY · PI TOBIAN, AARON A · 2011 to 2015
$684k
NIAID NIH HHS 1K23AI093152-01A1NIAID NIH HHS K23 AI093152NIAID NIH HHS T32AI102PHS HHS 1D43TWOO9578-01
6 · The paper itself

Abstract

A prospective observational study of 176 men coinfected with human immunodeficiency virus and herpes simplex virus type 2 (HSV-2) was conducted to assess whether their sexual partners may be at an increased risk of HSV-2 from male circumcision (MC) wounds. Preoperative and weekly penile lavage samples were tested for penile HSV-2 shedding. Prevalence risk ratios (PRRs) were estimated using Poisson regression. Detectable penile HSV-2 shedding was present in 9.7% of men (17 of 176) before MC, compared with 12.9% (22 of 170) at 1 week (PRR, 1.33; 95% confidence interval [CI], .74-2.38) and 14.8% (23 of 155) at 2 weeks (PRR, 1.50; 95% CI, .86-2.62) after MC. HSV-2 shedding was lower among men with healed MC wounds (adjusted PRR, 0.62; 95% CI, .35-1.08). Men undergoing MC should be counseled on sexual abstinence and condom use.

Indexed as

Circumcision, MaleVirus SheddingAdolescentAdultDisease Transmission, InfectiousHerpes GenitalisHerpesvirus 2, HumanHIV InfectionsHumansMalePrevalenceProspective StudiesRisk AssessmentUgandaWounds and InjuriesYoung Adultherpes simplex virus type 2 (HSV-2)human immunodeficiency virus (HIV)male circumcisionpenile viral sheddingUgandaviral load

Identifiers

PMID25943201
PMCPMC4621246
OpenAlexW2208108622

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.