ArticlePsychopharmacology2015
Escalation of cocaine self-administration in adulthood after social defeat of adolescent rats: role of social experience and adaptive coping behavior.
Article in Psychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Social isolation at adolescence: a systematic review on behaviour related to cocaine, amphetamine and nicotine use in rats and mice.Psychopharmacology · 2021Pooled it
- Psychiatric Risk Implications From Behavioral and Neural Effects of Adolescent Exposure to Environmental Insecticides: A Systematic Review of Rodent Studies.Biological psychiatry · 2026Review
- Adolescent social isolation increases social behavior in Wistar rats: Role of post-weaning isolation housing on Social Familiarity-induced Anxiolysis (SoFiA) and social memory in adulthood.Behavioural brain research · 2025Article
- Paternal morphine exposure in rats reduces social play in adolescent male progeny without affecting drug-taking behavior in juvenile males or female offspring.Molecular and cellular neurosciences · 2023Article
- Friend of the Devil: Negative Social Influences Driving Substance Use Disorders.Frontiers in behavioral neuroscience · 2022Review
- Chronic Physical and Vicarious Psychosocial Stress Alter Fentanyl Consumption and Nucleus Accumbens Rho GTPases in Male and Female C57BL/6 Mice.Frontiers in behavioral neuroscience · 2022Article
- Effect of early life social adversity on drug abuse vulnerability: Focus on corticotropin-releasing factor and oxytocin.Neuropharmacology · 2021Review
- Housing conditions during self-administration determine motivation for cocaine in mice following chronic social defeat stress.Psychopharmacology · 2021Article
- Methionine mediates resilience to chronic social defeat stress by epigenetic regulation of NMDA receptor subunit expression.Psychopharmacology · 2020Article
- Opposite regulation of conditioned place preference and intravenous drug self-administration in rodent models: Motivational and non-motivational examples.Neuroscience and biobehavioral reviews · 2020Review
- Sex chromosome complement influences vulnerability to cocaine in mice.Hormones and behavior · 2020Article
- Role of adolescent-formed, context-drug-associations on reinstatement of drug-seeking behavior in rats.Psychopharmacology · 2020Article
- Enduring effects of adolescent ketamine exposure on cocaine- and sucrose-induced reward in male and female C57BL/6 mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Non-pharmacological factors that determine drug use and addiction.Neuroscience and biobehavioral reviews · 2020Review
- Adolescent social isolation increases cocaine seeking in male and female mice.Behavioural brain research · 2019Article
- Ibogaine Administration Modifies GDNF and BDNF Expression in Brain Regions Involved in Mesocorticolimbic and Nigral Dopaminergic Circuits.Frontiers in pharmacology · 2019Article
- Social defeat stress and escalation of cocaine and alcohol consumption: Focus on CRF.Neurobiology of stress · 2018Review
- Negative consequences of early-life adversity on substance use as mediated by corticotropin-releasing factor modulation of serotonin activity.Neurobiology of stress · 2018Review
- Enhanced dopamine D2 autoreceptor function in the adult prefrontal cortex contributes to dopamine hypoactivity following adolescent social stress.The European journal of neuroscience · 2018Article
- A novel adolescent chronic social defeat model: reverse-Resident-Intruder Paradigm (rRIP) in male rats.Stress (Amsterdam, Netherlands) · 2018Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe link between adolescent social stress and substance abuse is modeled in social defeat of adolescent male rats, at an age when social experiences are essential for neurobehavioral maturation.
objectiveWe investigated the role of social experience and social defeat stress during adolescence on social behavior and cocaine self-administration (CocSelfAd) in early adulthood.
methodsWe manipulated social experience by housing male rats in pairs (PH) or singly (SH) on postnatal day (P) 21. In addition, rats were subjected to social defeat from P35-44. Social behavior was measured during the first and last social defeat in PH and SH adolescents and PH adults. After assessing the behavioral response to novelty and cocaine (P57-61), intrajugular catheters were implanted and CocSelfAd was analyzed.
resultsResidents were less aggressive toward PH adolescent intruders compared to PH adult intruders. Adults were submissive and defensive when attacked, whereas PH adolescents froze. In the course of repeated defeats, adolescent PH rats increased freezing, while SH rats decreased freezing. Longer attack-induced freezing after repeated defeats predicted escalated CocSelfAd in adulthood. PH controls acquired CocSelfAd more slowly than PH defeated and SH rats. Defeated PH rats increased CocSelfAd during progressive ratio schedules of reinforcement and during a 24-h continuous access binge compared to PH controls and SH defeated rats.
conclusionsSocial defeat in adolescence of PH rats caused persistent increases in adult CocSelfAd. Adolescent PH rats coped with attacks adaptively by increasing freezing behavior after repeated social defeats, a measure that predicted CocSelfAd in adulthood.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.