ArticlePsychopharmacology2015
Sex differences in the long-lasting consequences of adolescent ethanol exposure for the rewarding effects of cocaine in mice.
Article in Psychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- The role of polysubstance use in the development, maintenance, and treatment of stimulant use disorders.Pharmacological reviews · 2026Review
- Ethanol self-administration reduced the efficacy of a behavioral intervention to decrease cocaine choice in socially housed male and female monkeys.Drug and alcohol dependence · 2025Article
- Ethanol consumption prior to cocaine self-administration reduced vulnerability to cocaine reinforcement in socially subordinate female and male monkeys.Psychopharmacology · 2025Article
- Animal models of cocaine use: importance of social context and co-use.Trends in pharmacological sciences · 2025Review
- Cannabidiol or ketamine for preventing the impact of adolescent early drug initiation on voluntary ethanol consumption in adulthood.Frontiers in pharmacology · 2024Article
- Ethanol pre-exposure differentially impacts the rewarding and aversive effects of α-pyrrolidinopentiophenone (α-PVP): Implications for drug use and abuse.Pharmacology, biochemistry, and behavior · 2021Article
- Effect of chronic binge-like ethanol consumption on subsequent cocaine reinforcement in rhesus monkeys.Drug and alcohol dependence · 2021Article
- Drug addiction co-morbidity with alcohol: Neurobiological insights.International review of neurobiology · 2021Review
- One Is Not Enough: Understanding and Modeling Polysubstance Use.Frontiers in neuroscience · 2020Review
- Adolescent fluoxetine history impairs spatial memory in adult male, but not female, C57BL/6 mice.Journal of affective disorders · 2019Article
- Sugar Addiction: From Evolution to Revolution.Frontiers in psychiatry · 2018Review
- Effects of environmental enrichment upon ethanol-induced conditioned place preference and pre-frontal BDNF levels in adolescent and adult mice.Scientific reports · 2017Article
- Prior Exposure to Alcohol Has No Effect on Cocaine Self-Administration and Relapse in Rats: Evidence from a Rat Model that Does Not Support the Gateway Hypothesis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- Testing the Gateway Hypothesis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleThe practice of binge drinking is very common among adolescents of both sexes. It can have long-term consequences with respect to drug consumption during adulthood, but knowledge on these effects in females is limited.
objectivesThe long-lasting effects of intermittent exposure to ethanol (EtOH) during adolescence on different cocaine-elicited behaviours, including locomotor reactivity, conditioned place preference (CPP) and intravenous self-administration, were evaluated in male and female adult mice. It was hypothesized that an EtOH binge during adolescence would increase sensitivity to the effects of a sub-threshold dose of cocaine and has a differential impact on the drug's effects in males and females.
methodsAdolescent OF1 mice (postnatal day (PND) 26) underwent a 2-week pre-treatment schedule consisting of 16 doses of EtOH (2.5 g/kg) or saline (twice daily administrations separated by a 4-h interval i.p.) administered on two consecutive days separated by an interval of 2 days. Three weeks later (PND > 60), we assessed locomotor activity responses induced by an acute injection of different doses of cocaine in experiment 1 and the rewarding effects of cocaine on the CPP (1 mg/kg) and intravenous self-administration (1 mg/kg/infusion) paradigms in experiment 2.
resultsPre-exposure to EtOH during adolescence altered motor reactivity to cocaine in a dose- and sex-dependent manner, increased sensitivity to cocaine in CPP and enhanced self-administration in adult mice.
conclusionsThe effects of intermittent exposure to ethanol during adolescence are evident in adulthood, during which greater sensitivity and intake of cocaine is observed and differ in each sex.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.