ReviewSensors (Basel, Switzerland)2015
Fluorescence spectroscopy and chemometric modeling for bioprocess monitoring.
Review in Sensors (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 114 citations in OpenAlex.
- Second-Order Chemometric Classification ofACS omega · 2026Article
- Observability- and Identifiability-Guided Sensor-Set Design for Digital-Twin-Assisted Consolidated Bioprocessing.Sensors (Basel, Switzerland) · 2026Article
- Ergot alkaloid control in biotechnological processes and pharmaceuticals (a mini review).Frontiers in toxicology · 2024Review
- In-line monitoring of Bordetella pertussis cultivation using fluorescence spectroscopy.Bioprocess and biosystems engineering · 2023Article
- Excitation-Emission Matrix Fluorescence Spectroscopy Coupled with PARAFAC Modeling for Viability Prediction of Cells.ACS omega · 2023Article
- Assessing the capabilities of 2D fluorescence monitoring in microtiter plates with data-driven modeling for secondary substrate limitation experiments of Hansenula polymorpha.Journal of biological engineering · 2023Article
- rAAV Manufacturing: The Challenges of Soft Sensing during Upstream Processing.Bioengineering (Basel, Switzerland) · 2023Review
- Insights intoEngineering in life sciences · 2023Article
- Machine Learning-Assisted Synchronous Fluorescence Sensing Approach for Rapid and Simultaneous Quantification of Thiabendazole and Fuberidazole in Red Wine.Sensors (Basel, Switzerland) · 2022Article
- Sensors and Techniques for On-Line Determination of Cell Viability in Bioprocess Monitoring.Bioengineering (Basel, Switzerland) · 2022Review
- Reliable online measurement of population dynamics for filamentous co-cultures.Microbial biotechnology · 2022Article
- Online 2D Fluorescence Monitoring in Microtiter Plates Allows Prediction of Cultivation Parameters and Considerable Reduction in Sampling Efforts for Parallel Cultivations ofBioengineering (Basel, Switzerland) · 2022Article
- Application of Two-Dimensional Fluorescence Spectroscopy for the On-Line Monitoring of Teff-Based Substrate Fermentation Inoculated with Certain Probiotic Bacteria.Foods (Basel, Switzerland) · 2022Article
- Excitation-emission matrix fluorescence spectroscopy for cell viability testing in UV-treated cell culture.RSC advances · 2022Article
- Application of convolutional neural networks for prediction of disinfection by-products.Scientific reports · 2022Article
- Survey on Methods for Investigating Protein Functionality and Related Molecular Characteristics.Foods (Basel, Switzerland) · 2021Review
- Measurement Techniques to Resolve and Control Population Dynamics of Mixed-Culture Processes.Trends in biotechnology · 2021Review
- Effect of the use of Bacillus spp. on the characteristics of dissolved fluorescent organic matter and the phytochemical quality of Stevia rebaudiana grown in a recirculating aquaponic system.Environmental science and pollution research international · 2021Article
- Spectroscopic analysis of chia seeds.Scientific reports · 2021Article
- The ecology of wine fermentation: a model for the study of complex microbial ecosystems.Applied microbiology and biotechnology · 2021Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
On-line sensors for the detection of crucial process parameters are desirable for the monitoring, control and automation of processes in the biotechnology, food and pharma industry. Fluorescence spectroscopy as a highly developed and non-invasive technique that enables the on-line measurements of substrate and product concentrations or the identification of characteristic process states. During a cultivation process significant changes occur in the fluorescence spectra. By means of chemometric modeling, prediction models can be calculated and applied for process supervision and control to provide increased quality and the productivity of bioprocesses. A range of applications for different microorganisms and analytes has been proposed during the last years. This contribution provides an overview of different analysis methods for the measured fluorescence spectra and the model-building chemometric methods used for various microbial cultivations. Most of these processes are observed using the BioView® Sensor, thanks to its robustness and insensitivity to adverse process conditions. Beyond that, the PLS-method is the most frequently used chemometric method for the calculation of process models and prediction of process variables.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.