Evidence map›Paper›PMID 25942571›Full record

ArticleNucleus (Austin, Tex.)2015

ESCRTs breach the nuclear border.

Brant M Webster, C Patrick Lusk

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nucleus (Austin, Tex.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Review
  3. The LEM-ESCRT toolkit: Repair and maintenance of the nucleus.Frontiers in cell and developmental biology · 2022
    Review
  4. ESCRT-dependent control of membrane remodelling during cell division.Seminars in cell & developmental biology · 2018
    Review
  5. Review
  6. Article
  7. Review
  8. The ESCRT machinery: new roles at new holes.Current opinion in cell biology · 2016
    Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Brant M Webstera Yale School of Medicine ; New Haven , CT , USA.
C Patrick Lusk
University of New Haven · US

Funding

Skill Development for Diverse Scientific Careers: A New Course Predoctoral Program in Cellular and Molecular BiologyT32GM007223 · NIGMS · YALE UNIVERSITY · PI BASERGA, SUSAN J · 1985 to 2019
$31.0M
The mechanism of ESCRT-mediated surveillance of the nuclear envelope barrierR01GM105672 · NIGMS · YALE UNIVERSITY · PI LUSK, CHARLES PATRICK · 2013 to 2025
$4.6M
NIGMS NIH HHS R01 GM105672NIGMS NIH HHS T32 GM007223
6 · The paper itself

Abstract

The endosomal sorting complexes required for transport (ESCRT) are best known for their role in sorting ubiquitylated membrane proteins into endosomes. The most ancient component of the ESCRT machinery is ESCRT-III, which is capable of oligomerizing into a helical filament that drives the invagination and scission of membranes aided by the AAA ATPase, Vps4, in several additional subcellular contexts. Our recent study broadens the work of ESCRT-III by identifying its role in a quality control pathway at the nuclear envelope (NE) that ensures the normal biogenesis of nuclear pore complexes (NPCs). Here, we will elaborate on how we envision this mechanism to progress and incorporate ESCRT-III into an emerging model of nuclear pore formation. Moreover, we speculate there are additional roles for the ESCRT-III machinery at the NE that broadly function to ensure its integrity and the maintenance of the nuclear compartment.

Indexed as

Adenosine TriphosphatasesChromatinEndosomal Sorting Complexes Required for TransportEndosomesGene Expression Regulation, FungalMembrane GlycoproteinsMembrane ProteinsNuclear PoreNuclear ProteinsProtein BindingProtein TransportSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSignal TransductionAdenosine TriphosphatasesChromatinEndosomal Sorting Complexes Required for TransportHeh2 protein, S cerevisiaeMembrane GlycoproteinsMembrane ProteinsNuclear ProteinsPOM152 protein, S cerevisiaeSaccharomyces cerevisiae ProteinsVPS4 protein, S cerevisiaeendosomal sorting complex required for transportERAD, ER-Associated DegradationESCRT, Endosomal Sorting Complexes Required for TransportINM, Inner Nuclear MembraneLEM, Lap2, Emerin, MAN1membrane curvatureMVB, Multivesicular BodyNE, Nuclear EnvelopeNLS, Nuclear Localization SignalNPC, Nuclear Pore Complexnuclear envelopenuclear pore complexONM, Outer Nuclear Membranequality controlSINC, Storage of Improperly assembled Nuclear pore Complexes

Identifiers

PMID25942571
PMCPMC4615171
OpenAlexW1530240669

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.