ReviewNutrients2015
Dietary RNAs: New Stories Regarding Oral Delivery.
Review in Nutrients, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Article
- Yeast Efficiently Utilizes Ribosomal RNA-Derived Oligonucleotides as Bioavailable Nutrient Sources.Foods (Basel, Switzerland) · 2026Article
- Dietary bovine milk miRNAs transported in extracellular vesicles are partially stable during GI digestion, are bioavailable and reach target tissues but need a minimum dose to impact on gene expression.European journal of nutrition · 2022Article
- New frontiers of oral sciences: Focus on the source and biomedical application of extracellular vesicles.Frontiers in bioengineering and biotechnology · 2022Review
- Exosomes provide unappreciated carrier effects that assist transfers of their miRNAs to targeted cells; I. They are 'The Elephant in the Room'.RNA biology · 2021Review
- Xeno-miRNA in Maternal-Infant Immune Crosstalk: An Aid to Disease Alleviation.Frontiers in immunology · 2020Review
- Effect of microvesicles fromCell death discovery · 2020Article
- Safety Considerations for Humans and Other Vertebrates Regarding Agricultural Uses of Externally Applied RNA Molecules.Frontiers in plant science · 2020Review
- Epigenetic Gene Regulation by Dietary Compounds in Cancer Prevention.Advances in nutrition (Bethesda, Md.) · 2019Article
- The Dark Matter of Nutrition:Integrative medicine (Encinitas, Calif.) · 2019Article
- Intestinal permeability, digestive stability and oral bioavailability of dietary small RNAs.Scientific reports · 2018Article
- The atypical genesis and bioavailability of the plant-based small RNA MIR2911: Bulking up while breaking down.Molecular nutrition & food research · 2017Article
- Bioavailability of transgenic microRNAs in genetically modified plants.Genes & nutrition · 2017Article
- Formidable challenges to the notion of biologically important roles for dietary small RNAs in ingesting mammals.Genes & nutrition · 2017Review
- Diet-derived microRNAs: unicorn or silver bullet?Genes & nutrition · 2017Article
- New Insight into Inter-kingdom Communication: Horizontal Transfer of Mobile Small RNAs.Frontiers in microbiology · 2017Review
- Anomalous uptake and circulatory characteristics of the plant-based small RNA MIR2911.Scientific reports · 2016Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
microRNAs (miRNAs), a class of small RNAs, are important regulators of various developmental processes in both plants and animals. Several years ago, a report showed the detection of diet-derived plant miRNAs in mammalian tissues and their regulation of mammalian genes, challenging the traditional functions of plant miRNAs. Subsequently, multiple efforts have attempted to replicate these findings, with the results arguing against the uptake of plant dietary miRNAs in healthy consumers. Moreover, several reports suggest the potential for "false positive" detection of plant miRNAs in human tissues. Meanwhile, some research continues to suggest both the presence and function of dietary miRNAs in mammalian tissues. Here we review the recent literature and discuss the strengths and weaknesses of emerging work that suggests the feasibility of dietary delivery of miRNAs. We also discuss future experimental approaches to address this controversial topic.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.