ArticleJournal of acquired immune deficiency syndromes (1999)2015
Targeting pre-exposure prophylaxis among men who have sex with men in the United States and Peru: partnership types, contact rates, and sexual role.
Article in Journal of acquired immune deficiency syndromes (1999), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed.
- The mChoice App, an mHealth Tool for the Monitoring of Preexposure Prophylaxis Adherence and Sexual Behaviors in Young Men Who Have Sex With Men: Usability Evaluation.JMIR human factors · 2025Article
- A Pilot Study of a Sibling-Based Online Intervention to Increase PrEP Uptake and Willingness Among Latino MSM.AIDS education and prevention : official publication of the International Society for AIDS Education · 2024Article
- Barriers to Pre-Exposure Prophylaxis Uptake Among Online Male Sex Workers in the US.AIDS and behavior · 2022Article
- Greater Levels of Self-Reported Adherence to Pre-Exposure Prophylaxis (PrEP) are Associated with Increased Condomless Sex Among Men Who Have Sex with Men.AIDS and behavior · 2020Article
- Concomitant Utilization of Pre-Exposure Prophylaxis (PrEP) and Meningococcal Vaccine (MenACWY) Among Gay, Bisexual, and Other Men Who Have Sex with Men in Los Angeles County, California.Archives of sexual behavior · 2020Article
- The HIV epidemic in Latin America: accomplishments and challenges on treatment and prevention.Current opinion in HIV and AIDS · 2019Review
- Developing a Mobile App (LYNX) to Support Linkage to HIV/Sexually Transmitted Infection Testing and Pre-Exposure Prophylaxis for Young Men Who Have Sex With Men: Protocol for a Randomized Controlled Trial.JMIR research protocols · 2019Article
- Individual and Network Factors Associated With Racial Disparities in HIV Among Young Men Who Have Sex With Men: Results From the RADAR Cohort Study.Journal of acquired immune deficiency syndromes (1999) · 2019Article
- Article
- Body/Selves and Beyond: Men's Narratives of Sexual Behavior on PrEP.Medical anthropology · 2018Article
- Development of an Agent-Based Model to Investigate the Impact of HIV Self-Testing Programs on Men Who Have Sex With Men in Atlanta and Seattle.JMIR public health and surveillance · 2018Article
- The cost-effectiveness of HIV pre-exposure prophylaxis in men who have sex with men and transgender women at high risk of HIV infection in Brazil.Journal of the International AIDS Society · 2018Article
- Effects of contact network structure on epidemic transmission trees: implications for data required to estimate network structure.Statistics in medicine · 2018Article
- Article
- Incidence of Gonorrhea and Chlamydia Following Human Immunodeficiency Virus Preexposure Prophylaxis Among Men Who Have Sex With Men: A Modeling Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Article
- Validation of participant eligibility for pre-exposure prophylaxis: Baseline data from the PRELUDE demonstration project.PloS one · 2017Observational
- Article
- Impact of the Centers for Disease Control's HIV Preexposure Prophylaxis Guidelines for Men Who Have Sex With Men in the United States.The Journal of infectious diseases · 2016Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundWe aim to identify optimal strategies for deploying pre-exposure prophylaxis among men who have sex with men (MSM) in the United States and Peru to maximize population-level effectiveness in an efficient manner. We use epidemic models to simulate the impact of targeting strategies. Most studies have focused on targeting either the general population or high-risk MSM. Alternative strategies, including serodiscordant couples, may better balance effectiveness and efficiency.
methodsWe use dynamic stochastic sexual network models based on exponential-family random graph modeling, parameterized from behavioral surveys of MSM in the United States and Peru. These models represent main partnerships and casual contacts separately, permitting modeling of interventions targeting men whose risk derives from combinations of relational types. We also model varying rates of uptake and adherence to pre-exposure prophylaxis (PrEP). We assess sensitivity of results to risk compensation through increases in condomless casual contacts and condomless sex in main partnerships.
resultsTargeting all men who are not exclusively insertive has the largest impact on HIV incidence, but targeting only those with high levels of casual activity yields comparable results using fewer person-years on PrEP. The effect is robust to risk compensation in the United States, but less so in Peru. Targeting serodiscordant main partnerships does not significantly impact incidence, but requires fewer person-years on PrEP per infection averted than other strategies.
conclusionsPrEP could be effective in reducing new infections at the population level in both settings. Serodiscordant partnerships are an attractive component of a targeting program, but targeting should include other high-risk men.
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