ArticleJournal of acquired immune deficiency syndromes (1999)2015
HIV Infection Is Associated With Increased Risk for Acute Exacerbation of COPD.
Article in Journal of acquired immune deficiency syndromes (1999), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 48 citations in OpenAlex.
- Integrated multi-omics identifies CRP as a prognostic biomarker and reveals complement consumption in HIV-associated AECOPD.Frontiers in immunology · 2026Article
- Article
- Differences in emergency department visit characteristics and resource utilization for persons with human immunodeficiency virus, 2018-2019 compared with 2009-2010.BMC emergency medicine · 2025Article
- Chronic Obstructive Pulmonary Disease in People with HIV: an Evidence-Based Review.HIV/AIDS (Auckland, N.Z.) · 2025Review
- Baltimore oral epidemiology, disease effects, and HIV evaluation study (BEEHIVE) study protocol: a prospective cohort study.BMC oral health · 2024Article
- An Applicable Framework for Understanding Successful Aging of People Living with HIV and Comorbid Chronic Obstructive Pulmonary Disease.Nursing (Auckland, N.Z.) · 2024Article
- Design and methods of a randomized trial testing "Advancing care for COPD in people living with HIV by implementing evidence-based management through proactive E-consults (ACHIEVE)".Contemporary clinical trials · 2023Article
- HIV-associated lung disease.Nature reviews. Disease primers · 2023Review
- Circadian-Coupled Genes Expression and Regulation in HIV-Associated Chronic Obstructive Pulmonary Disease (COPD) and Lung Comorbidities.International journal of molecular sciences · 2023Review
- Human Immunodeficiency Virus-associated Chronic Obstructive Pulmonary Disease Is Characterized by Increased Small Airways Dysfunction on Computed Tomography Imaging.Annals of the American Thoracic Society · 2023Article
- COPD in People with HIV: Epidemiology, Pathogenesis, Management, and Prevention Strategies.International journal of chronic obstructive pulmonary disease · 2023Review
- Analyses of Factors Associated with Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Review.International journal of chronic obstructive pulmonary disease · 2023Review
- A Bibliometric Analysis of Comorbidity of COPD and Lung Cancer: Research Status and Future Directions.International journal of chronic obstructive pulmonary disease · 2023Article
- Epigenome-wide association analyses of active injection drug use.Drug and alcohol dependence · 2022Article
- Mortality among people who inject drugs: a prospective cohort followed over three decades in Baltimore, MD, USA.Addiction (Abingdon, England) · 2022Article
- SARS-CoV-2 and Human Immunodeficiency Virus: Pathogen Pincer Attack.HIV/AIDS (Auckland, N.Z.) · 2021Review
- Chronic obstructive pulmonary disease in HIV.Expert review of respiratory medicine · 2021Review
- Association of Lung Function With HIV-Related Quality of Life and Health Care Utilization in a High-Risk Cohort.Journal of acquired immune deficiency syndromes (1999) · 2020Article
- Lung function in men with and without HIV.AIDS (London, England) · 2020Observational
- Observational
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPoorly controlled HIV infection is associated with increased risk for chronic obstructive pulmonary disease (COPD). Acute exacerbations of COPD (AECOPD) are major contributors to morbidity and mortality. Little is known about the association between HIV infection and AECOPD.
methodsWe identified 167 individuals with spirometry-confirmed COPD from a longitudinal study of current or former injection drug users at risk or with HIV infection. AECOPD, defined as self-report of worsening breathing requiring treatment with antibiotics or steroids, was assessed at 6-month study visits. Multivariable logistic regression identified factors associated with AECOPD.
resultsOf 167 participants, the mean age was 52 years; 89% were black, 30% female, and 32% HIV infected (median CD4 count: 312 cells per milliliter, 46% with detectable HIV RNA). After adjusting for age, gender, smoking history, comorbidity treatment, and airflow obstruction severity, HIV was independently associated with a 2.47 increased odds of AECOPD [95% confidence interval (CI): 1.22 to 5.00]. Compared with HIV-uninfected persons, HIV-infected persons with undetectable (<50 copies/mL) HIV RNA levels and those with a CD4 count ≥350 cells per cubic millimeter demonstrated increased AECOPD (odds ratio, 2.91; 95% CI: 1.26 to 6.71; odds ratio, 4.16; 95% CI: 1.87 to 9.27, respectively). Higher AECOPD risk was observed with higher CD4 counts irrespective of treatment for comorbid diseases.
conclusionsHIV infection is independently associated with increased odds of AECOPD, potentially due to differences in treatment access and to variable disease manifestation by immune status. Providers should be aware that HIV infection may increase risk for AECOPD and that symptom may be more discernible with intact immune function.
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