ArticleeLife2015
Reverse-correlation analysis of navigation dynamics in Drosophila larva using optogenetics.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed.
- The larvalScience advances · 2026Article
- The larvalbioRxiv : the preprint server for biology · 2026Article
- Article
- Navigation strategies in Caenorhabditis elegans are differentially altered by learning.PLoS biology · 2025Article
- Article
- CRASH2p: Closed-loop Two Photon Imaging in a Freely Moving Animal.bioRxiv : the preprint server for biology · 2024Article
- Optogenetics Neuromodulation of the Nose.Behavioural neurology · 2024Review
- Sensorimotor transformation underlying odor-modulated locomotion in walking Drosophila.Nature communications · 2023Article
- Article
- Temporal novelty detection and multiple timescale integration drive Drosophila orientation dynamics in temporally diverse olfactory environments.PLoS computational biology · 2023Article
- Continuous, long-term crawling behavior characterized by a robotic transport system.bioRxiv : the preprint server for biology · 2023Article
- Stability of olfactory behavior syndromes in the Drosophila larva.Scientific reports · 2023Article
- The chemosensory system of theFly · 2022Review
- Validation of an Optogenetic Approach to the Study of Olfactory Behavior in the T-Maze ofInsects · 2022Article
- Optogenetic and thermogenetic manipulation of defined neural circuits and behaviors inLearning & memory (Cold Spring Harbor, N.Y.) · 2022Article
- Article
- Olfactory Sensing and Navigation in Turbulent Environments.Annual review of condensed matter physics · 2022Article
- Article
- A high-throughput method to deliver targeted optogenetic stimulation to moving C. elegans populations.PLoS biology · 2022Article
- Taste sensing and sugar detection mechanisms ineLife · 2021Article
1 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors.
Funding
Abstract
Neural circuits for behavior transform sensory inputs into motor outputs in patterns with strategic value. Determining how neurons along a sensorimotor circuit contribute to this transformation is central to understanding behavior. To do this, a quantitative framework to describe behavioral dynamics is needed. In this study, we built a high-throughput optogenetic system for Drosophila larva to quantify the sensorimotor transformations underlying navigational behavior. We express CsChrimson, a red-shifted variant of channelrhodopsin, in specific chemosensory neurons and expose large numbers of freely moving animals to random optogenetic activation patterns. We quantify their behavioral responses and use reverse-correlation analysis to uncover the linear and static nonlinear components of navigation dynamics as functions of optogenetic activation patterns of specific sensory neurons. We find that linear-nonlinear models accurately predict navigational decision-making for different optogenetic activation waveforms. We use our method to establish the valence and dynamics of navigation driven by optogenetic activation of different combinations of bitter-sensing gustatory neurons. Our method captures the dynamics of optogenetically induced behavior in compact, quantitative transformations that can be used to characterize circuits for sensorimotor processing and their contribution to navigational decision making.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.