ReviewJournal of AOAC International
Plant Sterols, Stanols, and Sitosterolemia.
Review in Journal of AOAC International. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Genome-wide association study and meta-analysis of phytosterols identifies a novel locus for serum levels of campesterol.Human genomics · 2024Pooled it
- Platelet proteomic profiling in sitosterolemia suggests thrombocytopenia is driven by lipid disorder and not platelet aberrations.Blood advances · 2024Article
- Gene variants and clinical characteristics of children with sitosterolemia.Lipids in health and disease · 2024Article
- Chemical and Biochemical Features of Spinasterol and Schottenol.Advances in experimental medicine and biology · 2024Article
- Clinical characteristics of sitosterolemic children with xanthomas as the first manifestation.Lipids in health and disease · 2022Article
- [Clinical characteristics analysis of a case of sitosterolemia due to mutation of ABCG5 gene in a child with thrombocytopenia and abnormal liver function].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2021Article
- Uptake of Vitamins DNutrients · 2021Article
- Review
- Sitosterolemia With Atherosclerosis in a Child: A Case Report.Frontiers in pediatrics · 2021Article
- Remediation ofFrontiers in genetics · 2021Article
- Oilseed crop sunflower (Food science & nutrition · 2020Review
- Genetic variability in the absorption of dietary sterols affects the risk of coronary artery disease.European heart journal · 2020Article
- Plasma oxyphytosterol concentrations are not associated with CVD status in Framingham Offspring Study participants.Journal of lipid research · 2019Article
- Multiscale Simulations of Biological Membranes: The Challenge To Understand Biological Phenomena in a Living Substance.Chemical reviews · 2019Article
- Clinical features and genetic analysis of childhood sitosterolemia: Two case reports and literature review.Medicine · 2019Review
- Progress and perspectives in plant sterol and plant stanol research.Nutrition reviews · 2018Review
- Network-based association analysis to infer new disease-gene relationships using large-scale protein interactions.PloS one · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Phytosterolemia (sitosterolemia) is a rare autosomal recessive sterol storage disease caused by mutations in either of the adenosine triphosphate (ATP) binding cassette transporter genes; (ABC) G5 or ABCG8, leading to impaired elimination of plant sterols and stanols, with their increased accumulation in the blood and tissues. Thus the disease is characterized by substantially elevated serum plant sterols and stanols, with moderate to high plasma cholesterol levels, and increased risk of premature atherosclerosis. Hematologic abnormalities including macrothrombocytopenia, stomatocytosis and hemolysis are frequently observed in sitosterolemia patients. Currently, ezetimibe, a sterol absorption inhibitor, is used as the routine treatment for sitosterolemia, with reported improvement in plant sterol levels and hemolytic parameters. This review summarizes the research related to the health impact of plant sterols and stanols on sitosterolemia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.