ArticleScientific reports2015
Macro-to-micro cortical vascular imaging underlies regional differences in ischemic brain.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed.
- Optical coherence tomography (OCT) and OCT angiography: Technological development and applications in brain science.Theranostics · 2025Review
- Panax notoginseng saponins promotes angiogenesis after cerebral ischemia-reperfusion injury.Journal of ginseng research · 2024Article
- Review
- Distribution of intraperitoneally administered deuterium-labeled water in aquaporin-4-knockout mouse brain after middle cerebral artery occlusion.Frontiers in neuroscience · 2022Article
- Retinal ischemia induces α-SMA-mediated capillary pericyte contraction coincident with perivascular glycogen depletion.Acta neuropathologica communications · 2019Article
- Monitoring Acute Stroke Progression: Multi-Parametric OCT Imaging of Cortical Perfusion, Flow, and Tissue Scattering in a Mouse Model of Permanent Focal Ischemia.IEEE transactions on medical imaging · 2019Article
- Optical coherence tomography angiography for noninvasive evaluation of angiogenesis in a limb ischemia mouse model.Scientific reports · 2019Article
- Insulin-like Growth Factor (IGF)-1 treatment stabilizes the microvascular cytoskeleton under ischemic conditions.Experimental neurology · 2019Article
- Monitoring Acute Stroke in Mouse Model Using Laser Speckle Imaging-Guided Visible-Light Optical Coherence Tomography.IEEE transactions on bio-medical engineering · 2018Article
- Upregulation of heme oxygenase-1 protected against brain damage induced by transient cerebral ischemia-reperfusion injury in rats.Experimental and therapeutic medicine · 2018Article
- Improved speckle contrast optical coherence tomography angiography.American journal of translational research · 2018Article
- Multipoint Tissue Circulation Monitoring with a Flexible Optical Probe.Scientific reports · 2017Article
- Review of optical coherence tomography based angiography in neuroscience.Neurophotonics · 2016Review
- Methods and algorithms for optical coherence tomography-based angiography: a review and comparison.Journal of biomedical optics · 2015Review
- Minimizing projection artifacts for accurate presentation of choroidal neovascularization in OCT micro-angiography.Biomedical optics express · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The ability to non-invasively monitor and quantify hemodynamic responses down to the capillary level is important for improved diagnosis, treatment and management of neurovascular disorders, including stroke. We developed an integrated multi-functional imaging system, in which synchronized dual wavelength laser speckle contrast imaging (DWLS) was used as a guiding tool for optical microangiography (OMAG) to test whether detailed vascular responses to experimental stroke in male mice can be evaluated with wide range sensitivity from arteries and veins down to the capillary level. DWLS enabled rapid identification of cerebral blood flow (CBF), prediction of infarct area and hemoglobin oxygenation over the whole mouse brain and was used to guide the OMAG system to hone in on depth information regarding blood volume, blood flow velocity and direction, vascular architecture, vessel diameter and capillary density pertaining to defined regions of CBF in response to ischemia. OMAG-DWLS is a novel imaging platform technology to simultaneously evaluate multiple vascular responses to ischemic injury, which can be useful in improving our understanding of vascular responses under pathologic and physiological conditions, and ultimately facilitating clinical diagnosis, monitoring and therapeutic interventions of neurovascular diseases.
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Registered trials
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