Evidence map›Paper›PMID 25941619›Full record

ArticleOncoimmunology2014

Vitamin B6 improves the immunogenicity of cisplatin-induced cell death.

Fernando Aranda, Norma Bloy, Lorenzo Galluzzi, Guido Kroemer, Laura Senovilla

Open access · goldAbstract read
In one paragraph

Article in Oncoimmunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 3 countries.

Fernando ArandaEquipe 11 labelisée par la Ligue Nationale contre le cancer; Centre de Recherche des Cordeliers ; Paris, France ; Université Paris Descartes/Paris 5 ; Sorbonne Paris Cité , Paris, France ; INSERM U1138; Paris, France ; Gustave Roussy Comprehensive Cancer Center ; Villejuif, France.
Norma BloyEquipe 11 labelisée par la Ligue Nationale contre le cancer; Centre de Recherche des Cordeliers ; Paris, France ; Université Paris Descartes/Paris 5 ; Sorbonne Paris Cité , Paris, France ; INSERM U1138; Paris, France ; Gustave Roussy Comprehensive Cancer Center ; Villejuif, France.
Lorenzo GalluzziEquipe 11 labelisée par la Ligue Nationale contre le cancer; Centre de Recherche des Cordeliers ; Paris, France ; Université Paris Descartes/Paris 5 ; Sorbonne Paris Cité , Paris, France ; INSERM U1138; Paris, France ; Gustave Roussy Comprehensive Cancer Center ; Villejuif, France.
Guido KroemerEquipe 11 labelisée par la Ligue Nationale contre le cancer; Centre de Recherche des Cordeliers ; Paris, France ; Université Paris Descartes/Paris 5 ; Sorbonne Paris Cité , Paris, France ; INSERM U1138; Paris, France ; Metabolomics and Cell Biology platforms; Gustave Roussy Comprehensive Cancer Center ; Villejuif, France ; Pôle de Biologie, Hôpital Européen Georges Pompidou ; AP-HP ; Paris, France.
Laura SenovillaEquipe 11 labelisée par la Ligue Nationale contre le cancer; Centre de Recherche des Cordeliers ; Paris, France ; INSERM U1138; Paris, France ; Gustave Roussy Comprehensive Cancer Center ; Villejuif, France ; Metabolomics and Cell Biology platforms; Gustave Roussy Comprehensive Cancer Center ; Villejuif, France ; INSERM U1015; Villejuif, France.
Délégation Paris 5 · FRInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have recently demonstrated that pyridoxine, a precursor of vitamin B6, increases the immunogenicity of non-small cell lung carcinoma (NSCLC) cells succumbing to cisplatin (cis-diamminedichloroplatinum(II), CDDP). Accordingly, pyridoxine promoted the antineoplastic activity of CDDP in NSCLC-bearing mice only in the presence of an intact immune system. These findings may have implications for the development of novel strategies to circumvent CDDP resistance.

Indexed as

apoptosisATPautophagycalreticulinCDDP, cis-diamminedichloroplatinum(II)endoplasmic reticulum stressHMGB1NSCLC, non-small cell lung carcinomaPDXKPDXK, pyridoxal kinasePN, pyridoxine

Identifiers

PMID25941619
PMCPMC4292417
OpenAlexW2085345629

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.