ReviewTherapeutic advances in neurological disorders2015
Exercise in the management of persons with multiple sclerosis.
Review in Therapeutic advances in neurological disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06051019 (Comparison Between the Effects on Fatigue of Aerobic Training Versus Balance Training in Patients With Multiple Sclerosis), which is not on this map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison Between the Effects on Fatigue of Aerobic Training Versus Balance Training in Patients With Multiple Sclerosis: a Randomised Crossover Trial.
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The impact of different exercise types on cognitive function in patients with multiple sclerosis: a systematic review and network meta-analysis.Journal of neurology · 2025Pooled it
- Effect of exercise therapy on quality of life of patients with multiple sclerosis in Iran: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2017Pooled it
- Exercise induces structural brain changes and elevates irisin levels and enhances functional performance in multiple sclerosis a pilot randomized study.Scientific reports · 2026Trial
- Impact of aerobic exercise on clinical and magnetic resonance imaging biomarkers in persons with multiple sclerosis: An exploratory randomized controlled trial.Journal of rehabilitation medicine · 2021Trial
- Fatigue, as measured using the Modified Fatigue Impact Scale, is a predictor of processing speed improvement induced by exercise in patients with multiple sclerosis: data from a randomized controlled trial.Journal of neurology · 2018Trial
- Review
- Multiple sclerosis in the elderly: a retrospective cohort study.Journal of neurology · 2024Article
- Rehabilitation therapy versus drug-only therapy in patients with multiple sclerosis.Turkish journal of medical sciences · 2024Observational
- The Early Initiation Advantages of Physical Therapy in Multiple Sclerosis-A Pilot Study.Life (Basel, Switzerland) · 2023Article
- Article
- Therapeutic Effects of the Pilates Method in Patients with Multiple Sclerosis: A Systematic Review.Journal of clinical medicine · 2022Review
- Alterations in Leg Muscle Glucose Uptake and Inter-Limb Asymmetry after a Single Session of tDCS in Four People with Multiple Sclerosis.Brain sciences · 2021Article
- When Much Is Too Much-Compared to Light Exercisers, Heavy Exercisers Report More Mental Health Issues and Stress, but Less Sleep Complaints.Healthcare (Basel, Switzerland) · 2021Article
- Impact of Moderate Individually Tailored Physical Activity in Multiple Sclerosis Patients with Fatigue on Functional, Cognitive, Emotional State, and Postural Stability.Brain sciences · 2021Article
- Multiple Sclerosis in Saudi Arabia: Clinical, Social, and Psychological Aspects of the Disease.Cureus · 2021Article
- A pilot study of the impact of an exercise intervention on brain structure, cognition, and psychosocial symptoms in individuals with relapsing-remitting multiple sclerosis.Pilot and feasibility studies · 2021Article
- Does Multiple Sclerosis Differently Impact Physical Activity in Women and Man? A Quantitative Study Based on Wearable Accelerometers.International journal of environmental research and public health · 2020Article
- Understanding the Deterioration of Gait, Postural Control, Lower Limb Strength and Perceived Fatigue Across the Disability Spectrum of People with Multiple Sclerosis.Journal of clinical medicine · 2020Article
- Evaluation of Power Production Asymmetry during Cycling in Persons with Multiple Sclerosis.International journal of environmental research and public health · 2019Article
- Telerehabilitation in Multiple Sclerosis: Results of a Randomized Feasibility and Efficacy Pilot Study.International journal of telerehabilitation · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For decades, persons with multiple sclerosis (MS) were counseled to avoid excessive physical activity and exercise because of concerns about worsening disease activity. Recent studies indicate that, not only can those with MS tolerate physical exercise, but that it is helpful in managing symptoms, preventing complications and comorbidities, and may possibly have neuroprotective actions. This article reviews previous studies on the effects of different exercise protocols in people with MS, and provides summaries of suggested exercise regimens that may be appropriate and beneficial for this patient population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.