Evidence map›Paper›PMID 25941472›Full record

ReviewFrontiers in cellular neuroscience2015

Molecular approaches for manipulating astrocytic signaling in vivo.

Alison X Xie, Jeremy Petravicz, Ken D McCarthy

Abstract readReview
In one paragraph

Review in Frontiers in cellular neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Essential Role of Astrocytes in Learning and Memory.International journal of molecular sciences · 2024
    Review
  5. Article
  6. Astrocytic contributions to Huntington's disease pathophysiology.Annals of the New York Academy of Sciences · 2023
    Review
  7. Review
  8. Article
  9. Article
  10. Dysregulation of Astrocyte-Neuronal Communication in Alzheimer's Disease.International journal of molecular sciences · 2021
    Review
  11. Article
  12. Review
  13. Extracellular ATP-Induced Alterations in Extracellular HFrontiers in cellular neuroscience · 2021
    Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alison X XieDepartment of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill Chapel Hill, NC, USA.
Jeremy PetraviczDepartment of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology Cambridge, MA, USA.
Ken D McCarthyDepartment of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill Chapel Hill, NC, USA.

Funding

NEURONAL/ASTROCYTIC COMMUNICATIONS IN VIVOR01NS020212 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MCCARTHY, KEN DOUGLAS · 1985 to 2013
$4.5M
Function of Astrocytic GPCR Signaling Cascades in Physiology and Mental IllnessR01MH099564 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MCCARTHY, KEN DOUGLAS · 2013 to 2016
$1.4M
NIMH NIH HHS R01 MH099564NINDS NIH HHS R01 NS020212
6 · The paper itself

Abstract

Astrocytes are the predominant glial type in the central nervous system and play important roles in assisting neuronal function and network activity. Astrocytes exhibit complex signaling systems that are essential for their normal function and the homeostasis of the neural network. Altered signaling in astrocytes is closely associated with neurological and psychiatric diseases, suggesting tremendous therapeutic potential of these cells. To further understand astrocyte function in health and disease, it is important to study astrocytic signaling in vivo. In this review, we discuss molecular tools that enable the selective manipulation of astrocytic signaling, including the tools to selectively activate and inactivate astrocyte signaling in vivo. Lastly, we highlight a few tools in development that present strong potential for advancing our understanding of the role of astrocytes in physiology, behavior, and pathology.

Indexed as

astrocyteDREADDGPCR signalingin vivoIP3R2 KO

Identifiers

PMID25941472
PMCPMC4403552

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.