Evidence map›Paper›PMID 25941463›Full record

ArticleThe Malaysian journal of medical sciences : MJMS2014

The brain in pain.

Asma Hayati Ahmad, Che Badariah Abdul Aziz

Abstract read
In one paragraph

Article in The Malaysian journal of medical sciences : MJMS, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Cognitive Functioning in Females with Endometriosis-Associated Chronic Pelvic Pain: A Literature Review.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2025
    Review
  2. Article
  3. Drugs used for pain management in gastrointestinal surgery and their implications.World journal of gastrointestinal pharmacology and therapeutics · 2024
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. The Study of Pain in Rats and Mice.Comparative medicine · 2019
    Review
  9. Love as a Modulator of Pain.The Malaysian journal of medical sciences : MJMS · 2017
    Review
  10. Pain in Times of Stress.The Malaysian journal of medical sciences : MJMS · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Asma Hayati AhmadDepartment of Physiology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan.
Che Badariah Abdul AzizDepartment of Physiology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pain, while salient, is highly subjective. A sensation perceived as painful by one person may be perceived as uncomfortable, not painful or even pleasant to others. Within the same person, pain may also be modulated according to its threat value and the context in which it is presented. Imaging techniques, such as functional magnetic resonance imaging and positron emission tomography, have identified a distributed network in the brain, the pain-relevant brain regions, that encode the sensory-discriminative aspect of pain, as well as its cognitive and affective/emotional factors. Current knowledge also implicates the prefrontal cortex as the modulatory area for pain, with its subdivisions forming the cortico-cortical pathway, an alternative pain modulatory pathway distinct from the descending modulatory pathway of pain. These findings from neuroimaging in human subjects have paved the way for the molecular mechanisms of pain modulation to be explored in animal studies.

Indexed as

affectivecognitivemodulationpainprefrontal cortex

Identifiers

PMID25941463
PMCPMC4405805

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.