Evidence map›Paper›PMID 25941433›Full record

ReviewJournal of clinical and experimental hepatology2015

Non-alcoholic Fatty Liver Disease and Metabolic Syndrome-Position Paper of the Indian National Association for the Study of the Liver, Endocrine Society of India, Indian College of Cardiology and Indian Society of Gastroenterology.

Ajay Duseja, Shivaram P Singh, Vivek A Saraswat, Subrat K Acharya, Yogesh K Chawla, Subhankar Chowdhury, Radha K Dhiman, Rohinivilasam V Jayakumar, Kaushal Madan, Sri P Misra and 6 more

Registry-linked trialOpen access · bronzeAbstract readReview
In one paragraph

Review in Journal of clinical and experimental hepatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04193982 (An Investigator Initiated Prospective, Four Arms Randomized Comparative Study of Efficacy and Safety of Saroglitazar, Vitamin E and Life Style Modification in Patients With Nonalcoholic Fatty Liver Disease), which is not on this map. Cited by 92 papers.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04193982 phase3unknown statusnot on this mapstarted 2021, after this paper: background citation

An Investigator Initiated Prospective, Four Arms Randomized Comparative Study of Efficacy and Safety of Saroglitazar, Vitamin E and Life Style Modification in Patients With Nonalcoholic Fatty Liver Disease (NAFLD)/ Non-alcoholic Steatohepatitis (NASH)

TypeinterventionalSponsorAsian Institute of Gastroenterology, IndiaRan2021 to 2021Enrolled250ConditionsNAFLDArmsSaroglitazar, Vitamin E, Combination drug, Lifestyle Changes
3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 172 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
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  11. Heart-liver co-management in MASLD: from concept to clinical practice.Nature reviews. Gastroenterology & hepatology · 2026
    Article
  12. Article
  13. Article
  14. Review
  15. Prevalence of Metabolic Dysfunction-Associated Steatotic Liver Disease: Mapping Across Different Indian Populations (MAP Study).Diabetes therapy : research, treatment and education of diabetes and related disorders · 2025
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review

32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 13 institutions in 1 country.

Ajay DusejaDepartment of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Shivaram P SinghDepartment of Gastroenterology, SCB Medical College, Cuttack, Odisha, India.
Vivek A SaraswatDepartment of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
Subrat K AcharyaDepartment of Gastroenterology, All India Institute of Medical Sciences, New Delhi, India.
Yogesh K ChawlaDepartment of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Subhankar ChowdhuryDepartment of Endocrinology, Institute of Postgraduate Medical Education & Research and SSKM Hospital, Kolkata, West Bengal, India.
Radha K DhimanDepartment of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Rohinivilasam V JayakumarDepartment of Endocrinology, Amrita Institute of Medical Sciences, Kochi, Kerala, India.
Kaushal MadanMedanta Institute of Digestive and Hepatobiliary Sciences, Medanta-The Medicity, Gurgaon, Haryana, India.
Sri P MisraDepartment of Gastroenterology, MotiLal Nehru Medical College, Allahabad, Uttar Pradesh, India.
Hrudananda MishraDepartment of Cardiology, SCB Medical College, Cuttack, Odisha, India.
Sunil K ModiDepartment of Cardiology, Indraprastha Apollo Hospital, New Delhi, India.
Arumugam MuruganathanThe Tamil Nadu Dr. M.G.R. Medical University & AG Hospital, Tirupur, Tamil Nadu, India.
Banshi SabooDepartment of Endocrinology, Diabetes Care & Hormone Clinic, Ahmedabad, Gujarat, India.
Rakesh SahayOsmania Medical College & Osmania General Hospital, Hyderabad, Andhra Pradesh & MediCiti Hospital, Hyderabad, Andhra Pradesh, India.
Rajesh UpadhyayDepartment of Gastroenterology, Max Super Speciality Hospital, Shalimar Bagh, New Delhi, India.
Post Graduate Institute of Medical Education and Research · INSriram Chandra Bhanja Medical College Hospital · INAll India Institute of Medical Sciences · INAmrita Institute of Medical Sciences and Research Centre · INDiabetes Care & Hormone Clinic · INIndraprastha Apollo Hospitals · INInstitute of Post Graduate Medical Education and Research · INMax Super Speciality Hospital · INMedanta The Medicity · INMotilal Nehru Medical College · INOsmania Medical College · INSanjay Gandhi Post Graduate Institute of Medical Sciences · INTamil Nadu Dr. M.G.R. Medical University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-alcoholic fatty liver disease (NAFLD) is closely associated with metabolic syndrome. Prevalence of metabolic risk factors including diabetes mellitus, obesity, etc. is rapidly increasing in India putting this population at risk for NAFLD. Patients with NAFLD are at increased risk for liver-related morbidity and mortality and also cardiovascular disease risk and increased incidence of diabetes mellitus on long-term follow-up. Management of patients with NAFLD may require a multi-disciplinary approach involving not only the hepatologists but also the internists, cardiologists, and endocrinologists. This position paper which is a combined effort of the Indian National Association for Study of the Liver (INASL), Endocrine Society of India (ESI), Indian College of Cardiology (ICC) and the Indian Society of Gastroenterology (ISG) defines the spectrum of NAFLD and the association of NAFLD with insulin resistance and metabolic syndrome besides suggesting preferred approaches for the diagnosis and management of patients with NAFLD in the Indian context.

Indexed as

ALT, Alanine AminotransferaseAPO C3, Apolipoprotein C3ARFI, Acoustic Radiation Forced ImpulseAST, Aspartate AminotransferaseATPIII, Adult Treatment Panel IIIBMI, Body mass indexCAD, Coronary artery diseaseCC, Cryptogenic CirrhosisCIMT, Carotid Intima Media ThicknessCK 18, Cytokeratin 18cryptogenic cirrhosisCT, Computed TomographyDM, Diabetes MellitusEBP, Enhancer-Binding ProteinEMA, Anti-Endomysial antibodiesFFA, Free Fatty AcidsFMD, Flow-Mediated VasodilatationFPG, Fasting Plasma GlucoseGTT, Glucose Tolerance TestHCC, Hepatocellular CarcinomaHOMA-IR, Homeostasis Model Assessment for Insulin ResistanceHTG, Hepatic triglycerideHTN, HypertensionIFG, Impaired Fasting GlucoseIGT, Impaired Glucose ToleranceIKK-β, Inhibitor of nuclear factor kappa-B kinase betainsulin resistanceIR, Insulin resistanceIRS-1, Insulin Receptor Substrate-1ITT, Insulin Tolerance TestLFTs, Liver Function TestsMRE, Magnetic Resonance ElastographyMS, Metabolic syndromeNAFLDNAFLD, Non-alcoholic fatty liver diseaseNASHNASH, Non-Alcoholic SteatohepatitisNF-κβ, Nuclear Factor Kappa Βnonalcoholic steatohepatitisPCOS, Polycystic Ovarian SyndromePPG, Post-Prandial GlucosePROCAM, Prospective Cardiovascular Munster studySREBP, Sterol-Regulatory Element-Binding ProteinT2DM, Type 2 Diabetes MellitusTE, Transient elastographyTG, TriglyceridesTTG, Anti-tissue transglutaminaseVHCC, Virus-related HCCVLDL, Very Low Density LipoproteinWHO, World Health Organization

Identifiers

PMID25941433
PMCPMC4415196
OpenAlexW2060089767

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.