Evidence map›Paper›PMID 25941431›Full record

ReviewJournal of clinical and experimental hepatology2015

Portal vein thrombosis.

Yogesh K Chawla, Vijay Bodh

Abstract readReview
In one paragraph

Review in Journal of clinical and experimental hepatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  13. Endovascular Treatment for Acute Portal Vein Thrombosis.Interventional radiology (Higashimatsuyama-shi (Japan) · 2025
    Review
  14. Article
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20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Yogesh K ChawlaDepartment of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India.
Vijay BodhDepartment of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Portal vein thrombosis is an important cause of portal hypertension. PVT occurs in association with cirrhosis or as a result of malignant invasion by hepatocellular carcinoma or even in the absence of associated liver disease. With the current research into its genesis, majority now have an underlying prothrombotic state detectable. Endothelial activation and stagnant portal blood flow also contribute to formation of the thrombus. Acute non-cirrhotic PVT, chronic PVT (EHPVO), and portal vein thrombosis in cirrhosis are the three main variants of portal vein thrombosis with varying etiological factors and variability in presentation and management. Procoagulant state should be actively investigated. Anticoagulation is the mainstay of therapy for acute non-cirrhotic PVT, with supporting evidence for its use in cirrhotic population as well. Chronic PVT (EHPVO) on the other hand requires the management of portal hypertension as such and with role for anticoagulation in the setting of underlying prothrombotic state, however data is awaited in those with no underlying prothrombotic states. TIPS and liver transplant may be feasible even in the setting of PVT however proper selection of candidates and type of surgery is warranted. Thrombolysis and thrombectomy have some role. TARE is a new modality for management of HCC with portal vein invasion.

Indexed as

ACLA, anti-cardiolipin antibodyacute and chronicAFP, alpha feto proteinanticoagulationBCS, Budd-Chiari syndromeCDUS, color doppler ultrasonographyCT, computed tomographyCTP, Child Turcotte PughEHPVO, extra hepatic portal venous obstructionEST, endoscopic sclerotherapyHCC, hepatocellular carcinomaHVPG, hepatic venous pressure gradientIGF-1, insulin like growth factor-1IGFBP-3, insulin like growth factor binding protein-3imagingINR, international normalized ratioJAK-2, Janus kinase 2LA, lupus anticoagulantLMWH, low molecular weight heparinMELD, model for end stage liver diseaseMPD, myeloproliferative disorderMRI, magnetic resonance imagingMTHFR, methylenetetrahydrofolate reductaseMVT, mesenteric vein thrombosisOCPs, oral contraceptive pillsPAI-1 4G-4G, plasminogen activator inhibitor type 1- 4G/4G genotypePNH, paroxysmal nocturnal hemoglobinuriaprothromboticPV, portal veinPVTPVT, portal vein thrombosisPWUS, Pulsed Wave ultrasonographyRFA, radio frequency ablationrtPA, recombinant tissue plasminogen activatorSMA, superior mesenteric arterySMV, superior mesenteric veinTAFI, thrombin activatable fibrinolysis inhibitorTARE, Trans arterial radioembolizationTB, tuberculosisTIPS, transjugular intrahepatic portosystemic shuntUFH, unfractionated heparin

Identifiers

PMID25941431
PMCPMC4415192

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.