ArticleProceedings of the National Academy of Sciences of the United States of America2015
Antigenic cooperation among intrahost HCV variants organized into a complex network of cross-immunoreactivity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 49 citations in OpenAlex.
- Exploring cooperation among social pathogens: a computational perspective.FEMS microbiology reviews · 2026Review
- A graph homomorphism approach for unraveling histories of metastatic cancers and viral outbreaks under evolutionary constraints.Nature communications · 2025Article
- Rapid glycoprotein evolution enables variant interactions in herpes simplex virus type 1.Virus evolution · 2025Article
- Patterns of the within-host evolution of human norovirus in immunocompromised individuals and implications for treatment.EBioMedicine · 2024Article
- Open questions in the social lives of viruses.Journal of evolutionary biology · 2023Review
- Reconstruction of Viral Variants via Monte Carlo Clustering.Journal of computational biology : a journal of computational molecular cell biology · 2023Article
- The evolution of cheating in viruses.Nature communications · 2021Review
- Accurate assembly of minority viral haplotypes from next-generation sequencing through efficient noise reduction.Nucleic acids research · 2021Article
- Technology dictates algorithms: recent developments in read alignment.Genome biology · 2021Review
- Quantitative differences between intra-host HCV populations from persons with recently established and persistent infections.Virus evolution · 2021Article
- Analysis of heterogeneous genomic samples using image normalization and machine learning.BMC genomics · 2020Article
- Graph fractal dimension and the structure of fractal networks.Journal of complex networks · 2020Article
- Antigenic Variability.Frontiers in immunology · 2020Article
- Local immunodeficiency: Minimal networks and stability.Mathematical biosciences · 2019Article
- Bottlenecks in the transmission of porcine reproductive and respiratory syndrome virus (PRRSV1) to naïve pigs and the quasi-species variation of the virus during infection in vaccinated pigs.Veterinary research · 2018Article
- Beneficial coinfection can promote within-host viral diversity.Virus evolution · 2018Article
- Transmissibility of intra-host hepatitis C virus variants.BMC genomics · 2017Article
- Sociovirology: Conflict, Cooperation, and Communication among Viruses.Cell host & microbe · 2017Article
- Transmission Bottleneck Size Estimation from Pathogen Deep-Sequencing Data, with an Application to Human Influenza A Virus.Journal of virology · 2017Article
- Toward a microbial Neolithic revolution in buildings.Microbiome · 2016Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatitis C virus (HCV) has the propensity to cause chronic infection. Continuous immune escape has been proposed as a mechanism of intrahost viral evolution contributing to HCV persistence. Although the pronounced genetic diversity of intrahost HCV populations supports this hypothesis, recent observations of long-term persistence of individual HCV variants, negative selection increase, and complex dynamics of viral subpopulations during infection as well as broad cross-immunoreactivity (CR) among variants are inconsistent with the immune-escape hypothesis. Here, we present a mathematical model of intrahost viral population dynamics under the condition of a complex CR network (CRN) of viral variants and examine the contribution of CR to establishing persistent HCV infection. The model suggests a mechanism of viral adaptation by antigenic cooperation (AC), with immune responses against one variant protecting other variants. AC reduces the capacity of the host's immune system to neutralize certain viral variants. CRN structure determines specific roles for each viral variant in host adaptation, with variants eliciting broad-CR antibodies facilitating persistence of other variants immunoreacting with these antibodies. The proposed mechanism is supported by empirical observations of intrahost HCV evolution. Interference with AC is a potential strategy for interruption and prevention of chronic HCV infection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.