ArticleProceedings of the National Academy of Sciences of the United States of America2015
Extreme selective sweeps independently targeted the X chromosomes of the great apes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 91 citations in OpenAlex.
- A curated genome-scale nucleotide diversity panel of non-human primates.Genome biology · 2026Article
- Genomic evidence for males of exceptional reproductive output (ERO) in apes and humans.National science review · 2025Article
- Comparative Patterns of Variation on the X Chromosome and Autosomes: The Role of the Breeding Sex Ratio.bioRxiv : the preprint server for biology · 2025Article
- Local genetic adaptation to habitat in wild chimpanzees.Science (New York, N.Y.) · 2025Article
- Sperm competition intensity shapes divergence in both sperm morphology and reproductive genes across murine rodents.Evolution; international journal of organic evolution · 2024Article
- Local genetic adaptation to habitat in wild chimpanzees.bioRxiv : the preprint server for biology · 2024Article
- Inference of selective forces on house mouse genomes during secondary contact in East Asia.Genome research · 2024Article
- Enrichment of hard sweeps on the X chromosome compared to autosomes in six Drosophila species.Genetics · 2024Article
- Enrichment of hard sweeps on the X chromosome compared to autosomes in six Drosophila species.bioRxiv : the preprint server for biology · 2023Article
- Trio-binning of a hinny refines the comparative organization of the horse and donkey X chromosomes and reveals novel species-specific features.Scientific reports · 2023Article
- Genetic conflict and the origin of multigene families: implications for sex chromosome evolution.Proceedings. Biological sciences · 2023Review
- Extraordinary selection on the human X chromosome associated with archaic admixture.Cell genomics · 2023Article
- Enrichment of Hard Sweeps on the X Chromosome in Drosophila melanogaster.Molecular biology and evolution · 2023Article
- The contribution of sex chromosome conflict to disrupted spermatogenesis in hybrid house mice.Genetics · 2022Article
- Dynamic molecular evolution of a supergene with suppressed recombination in white-throated sparrows.eLife · 2022Article
- Satellite DNA-mediated diversification of a sex-ratio meiotic drive gene family in Drosophila.Nature ecology & evolution · 2021Article
- Genomic architecture constrained placental mammal X Chromosome evolution.Genome research · 2021Article
- Population Genomics of the Maize Pathogen Ustilago maydis: Demographic History and Role of Virulence Clusters in Adaptation.Genome biology and evolution · 2021Article
- Chromosome X-wide Analysis of Positive Selection in Human Populations: Common and Private Signals of Selection and its Impact on Inactivated Genes and Enhancers.Frontiers in genetics · 2021Article
- Battle of the Sex Chromosomes: Competition between X and Y Chromosome-Encoded Proteins for Partner Interaction and Chromatin Occupancy Drives Multicopy Gene Expression and Evolution in Muroid Rodents.Molecular biology and evolution · 2020Article
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Authors and funding
10 authors at 20 institutions in 10 countries.
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Abstract
The unique inheritance pattern of the X chromosome exposes it to natural selection in a way that is different from that of the autosomes, potentially resulting in accelerated evolution. We perform a comparative analysis of X chromosome polymorphism in 10 great ape species, including humans. In most species, we identify striking megabase-wide regions, where nucleotide diversity is less than 20% of the chromosomal average. Such regions are found exclusively on the X chromosome. The regions overlap partially among species, suggesting that the underlying targets are partly shared among species. The regions have higher proportions of singleton SNPs, higher levels of population differentiation, and a higher nonsynonymous-to-synonymous substitution ratio than the rest of the X chromosome. We show that the extent to which diversity is reduced is incompatible with direct selection or the action of background selection and soft selective sweeps alone, and therefore, we suggest that very strong selective sweeps have independently targeted these specific regions in several species. The only genomic feature that we can identify as strongly associated with loss of diversity is the location of testis-expressed ampliconic genes, which also have reduced diversity around them. We hypothesize that these genes may be responsible for selective sweeps in the form of meiotic drive caused by an intragenomic conflict in male meiosis.
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