Evidence map›Paper›PMID 25941337›Full record

ArticleCancer discovery2015

Tumor twitter: cellular communication in the breast cancer stem cell niche.

Michael D Brooks, Max S Wicha

Open access · bronzeAbstract readComment
In one paragraph

Article in Cancer discovery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. HighMedicina (Kaunas, Lithuania) · 2023
    Article
  4. Article
  5. Epithelial Stem Cells: Making, Shaping and Breaking the Niche.Advances in experimental medicine and biology · 2022
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Cytokines, breast cancer stem cells (BCSCs) and chemoresistance.Clinical and translational medicine · 2018
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Michael D BrooksComprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
Max S WichaComprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan. mwicha@med.umich.edu.
University of Michigan · US

Funding

Regulation of Breast Stem Cells by the MicroenvironmentR01CA101860 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WICHA, MAX S. · 2004 to 2013
$2.4M
Stem Cell Self-Renewal mammary CarcinogenesisR01CA129765 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WICHA, MAX S. · 2008 to 2015
$2.4M
NCI NIH HHS R01 CA101860NCI NIH HHS R01-CA101860-06NCI NIH HHS R01 CA129765NCI NIH HHS R01-CA129765-06A1
6 · The paper itself

Abstract

Communication between the diverse assortment of cells that constitute the tumor microenvironment plays an important role in tumor development. Using a p53-null mouse model, Zhang and colleagues describe a novel feedback loop involving breast cancer stem cells and their progeny mediated by WNT2, CXCL12, and IL6.

Indexed as

AnimalsBreast NeoplasmsFemaleHumansTumor Suppressor Protein p53Tumor Suppressor Protein p53

Identifiers

PMID25941337
PMCPMC4422104
OpenAlexW1966923475

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.