ArticleJournal of immunology (Baltimore, Md. : 1950)2015
Diverse inflammatory cytokines induce selectin ligand expression on murine CD4 T cells via p38α MAPK.
Article in Journal of immunology (Baltimore, Md. : 1950), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- IL-12 mRNA-LNP promotes dermal resident memory CD4NPJ vaccines · 2025Article
- Immune Cell Migration to Cancer.Cells · 2024Review
- Immune cell trafficking: a novel perspective on the gut-skin axis.Inflammation and regeneration · 2024Review
- Pan-selectin inhibitors as potential therapeutics for COVID-19 treatment: in silico screening study.Glycobiology · 2021Article
- Surface Phenotype Changes and Increased Response to Oxidative Stress in CD4Biomedicines · 2021Article
- GCNT1-MediatedJournal of immunology (Baltimore, Md. : 1950) · 2020Article
- Selectins in cancer immunity.Glycobiology · 2018Review
- Fucosyltransferase Induction during Influenza Virus Infection Is Required for the Generation of Functional Memory CD4Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Cytokine- and TCR-Mediated Regulation of T Cell Expression of Ly6C and Sca-1.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Article
- Effector and Regulatory T Cells Roll at High Shear Stress by Inducible Tether and Sling Formation.Cell reports · 2017Article
- IL-18 Drives ILC3 Proliferation and Promotes IL-22 Production via NF-κB.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- T-lymphocyte homing: an underappreciated yet critical hurdle for successful cancer immunotherapy.Laboratory investigation; a journal of technical methods and pathology · 2017Review
- TGF-β Controls the Formation of Kidney-Resident T Cells via Promoting Effector T Cell Extravasation.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Regulation of T Cell Trafficking by Enzymatic Synthesis of O-Glycans.Frontiers in immunology · 2017Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Selectins are glycan-binding adhesion molecules that mediate the initial steps of leukocyte recognition of endothelium. Cytokines control numerous aspects of CD4 Th cell differentiation, but how cytokines control the induction of ligands for E- and P-selectin on Th cell subsets remains poorly understood. Among 20 cytokines that affect Th cell differentiation, we identified six that induce expression of selectin ligands on murine CD4 T cells above the low levels associated with TCR engagement: IL-12, IL-18, IL-27, IL-9, IL-25, and TGF-β1. Collectively, these six cytokines could potentially account for selectin ligand expression on all of the currently defined nonsessile Th cell lineages, including Th1, Th2, Th9, and Th17 cells, as well as regulatory T cells. Induction of selectin ligand expression by each of these six cytokines was almost completely inhibited by pharmacologic inhibition of p38 MAPK, but not other MAPKs, or by conditional genetic deletion of p38α MAPK. Analysis of the expression of key glycosyltransferase genes revealed that p38α signaling was selectively required for induction of Fut7 and Gcnt1 but not for the induction of St3gal4 or St3gal6. Constitutively active MKK6, an immediate upstream activator of p38 MAPK, induced selectin ligand expression equivalent to that of cytokines, and this induction was completely dependent on the expression of p38α. Our results identify the repertoire of cytokines responsible for selectin ligand induction on CD4 T cells and provide a mechanistic link between Th cell development and T cell migration.
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