Evidence map›Paper›PMID 25941314›Full record

ArticlePlant physiology2015

MicroRNA167-Directed Regulation of the Auxin Response Factors GmARF8a and GmARF8b Is Required for Soybean Nodulation and Lateral Root Development.

Youning Wang, Kexue Li, Liang Chen, Yanmin Zou, Haipei Liu, Yinping Tian, Dongxiao Li, Rui Wang, Fang Zhao, Brett J Ferguson and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plant physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed
25.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

102 citing papers in PubMed, 213 citations in OpenAlex.

  1. Review
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  3. RNA regulation in plants.Science China. Life sciences · 2026
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  4. Genome-Wide Identification and Expression Profiling of theInternational journal of molecular sciences · 2026
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  15. MicroRNA gatekeepers: Orchestrating rhizospheric dynamics.Journal of integrative plant biology · 2025
    Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article

42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Youning WangKey State Laboratory of Plant Cell and Chromosome Engineering, Center of Agricultural Resources Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Shijiazhuang, Hebei 050021, China (Y.W., K.L., L.C., Y.Z., H.L., Y.T., D.L., R.W., F.Z., X.L.); andCentre for Integrative Legume Research, University of Queensland, Brisbane, St. Lucia, Queensland 4072, Australia (B.J.F., P.M.G.).
Kexue LiKey State Laboratory of Plant Cell and Chromosome Engineering, Center of Agricultural Resources Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Shijiazhuang, Hebei 050021, China (Y.W., K.L., L.C., Y.Z., H.L., Y.T., D.L., R.W., F.Z., X.L.); andCentre for Integrative Legume Research, University of Queensland, Brisbane, St. Lucia, Queensland 4072, Australia (B.J.F., P.M.G.).
Liang ChenKey State Laboratory of Plant Cell and Chromosome Engineering, Center of Agricultural Resources Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Shijiazhuang, Hebei 050021, China (Y.W., K.L., L.C., Y.Z., H.L., Y.T., D.L., R.W., F.Z., X.L.); andCentre for Integrative Legume Research, University of Queensland, Brisbane, St. Lucia, Queensland 4072, Australia (B.J.F., P.M.G.).
Yanmin ZouKey State Laboratory of Plant Cell and Chromosome Engineering, Center of Agricultural Resources Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Shijiazhuang, Hebei 050021, China (Y.W., K.L., L.C., Y.Z., H.L., Y.T., D.L., R.W., F.Z., X.L.); andCentre for Integrative Legume Research, University of Queensland, Brisbane, St. Lucia, Queensland 4072, Australia (B.J.F., P.M.G.).
Haipei LiuKey State Laboratory of Plant Cell and Chromosome Engineering, Center of Agricultural Resources Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Shijiazhuang, Hebei 050021, China (Y.W., K.L., L.C., Y.Z., H.L., Y.T., D.L., R.W., F.Z., X.L.); andCentre for Integrative Legume Research, University of Queensland, Brisbane, St. Lucia, Queensland 4072, Australia (B.J.F., P.M.G.).ORCID http://orcid.org/0000-0002-1852-4537
Yinping TianKey State Laboratory of Plant Cell and Chromosome Engineering, Center of Agricultural Resources Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Shijiazhuang, Hebei 050021, China (Y.W., K.L., L.C., Y.Z., H.L., Y.T., D.L., R.W., F.Z., X.L.); andCentre for Integrative Legume Research, University of Queensland, Brisbane, St. Lucia, Queensland 4072, Australia (B.J.F., P.M.G.).
Dongxiao LiKey State Laboratory of Plant Cell and Chromosome Engineering, Center of Agricultural Resources Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Shijiazhuang, Hebei 050021, China (Y.W., K.L., L.C., Y.Z., H.L., Y.T., D.L., R.W., F.Z., X.L.); andCentre for Integrative Legume Research, University of Queensland, Brisbane, St. Lucia, Queensland 4072, Australia (B.J.F., P.M.G.).
Rui WangKey State Laboratory of Plant Cell and Chromosome Engineering, Center of Agricultural Resources Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Shijiazhuang, Hebei 050021, China (Y.W., K.L., L.C., Y.Z., H.L., Y.T., D.L., R.W., F.Z., X.L.); andCentre for Integrative Legume Research, University of Queensland, Brisbane, St. Lucia, Queensland 4072, Australia (B.J.F., P.M.G.).
Fang ZhaoKey State Laboratory of Plant Cell and Chromosome Engineering, Center of Agricultural Resources Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Shijiazhuang, Hebei 050021, China (Y.W., K.L., L.C., Y.Z., H.L., Y.T., D.L., R.W., F.Z., X.L.); andCentre for Integrative Legume Research, University of Queensland, Brisbane, St. Lucia, Queensland 4072, Australia (B.J.F., P.M.G.).
Brett J FergusonKey State Laboratory of Plant Cell and Chromosome Engineering, Center of Agricultural Resources Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Shijiazhuang, Hebei 050021, China (Y.W., K.L., L.C., Y.Z., H.L., Y.T., D.L., R.W., F.Z., X.L.); andCentre for Integrative Legume Research, University of Queensland, Brisbane, St. Lucia, Queensland 4072, Australia (B.J.F., P.M.G.).
Peter M GresshoffKey State Laboratory of Plant Cell and Chromosome Engineering, Center of Agricultural Resources Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Shijiazhuang, Hebei 050021, China (Y.W., K.L., L.C., Y.Z., H.L., Y.T., D.L., R.W., F.Z., X.L.); andCentre for Integrative Legume Research, University of Queensland, Brisbane, St. Lucia, Queensland 4072, Australia (B.J.F., P.M.G.).
Xia LiKey State Laboratory of Plant Cell and Chromosome Engineering, Center of Agricultural Resources Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Shijiazhuang, Hebei 050021, China (Y.W., K.L., L.C., Y.Z., H.L., Y.T., D.L., R.W., F.Z., X.L.); andCentre for Integrative Legume Research, University of Queensland, Brisbane, St. Lucia, Queensland 4072, Australia (B.J.F., P.M.G.) xli@genetics.ac.cn.ORCID http://orcid.org/0000-0002-7095-9183
The University of Queensland · AUInstitute of Genetics and Developmental Biology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Legume root nodules convert atmospheric nitrogen gas into ammonium through symbiosis with a prokaryotic microsymbiont broadly called rhizobia. Auxin signaling is required for determinant nodule development; however, the molecular mechanism of auxin-mediated nodule formation remains largely unknown. Here, we show in soybean (Glycine max) that the microRNA miR167 acts as a positive regulator of lateral root organs, namely nodules and lateral roots. miR167c expression was up-regulated in the vasculature, pericycle, and cortex of soybean roots following inoculation with Bradyrhizobium japonicum strain USDA110 (the microsymbiont). It was found to positively regulate nodule numbers directly by repressing the target genes GmARF8a and GmARF8b (homologous genes of Arabidopsis [Arabidopsis thaliana] AtARF8 that encode auxin response factors). Moreover, the expression of miR167 and its targets was up- and down-regulated by auxin, respectively. The miR167-GmARF8 module also positively regulated nodulation efficiency under low microsymbiont density, a condition often associated with environmental stress. The regulatory role of miR167 on nodule initiation was dependent on the Nod factor receptor GmNFR1α, and it acts upstream of the nodulation-associated genes nodule inception, nodulation signaling pathway1, early nodulin40-1, NF-YA1 (previously known as HAEM activator protein2-1), and NF-YA2. miR167 also promoted lateral root numbers. Collectively, our findings establish a key role for the miR167-GmARF8 module in auxin-mediated nodule and lateral root formation in soybean.

Indexed as

Gene Expression Regulation, PlantBradyrhizobiumGene Knockdown TechniquesGenes, PlantGlycine maxIndoleacetic AcidsMicroRNAsModels, BiologicalPlant ProteinsPlant Root NodulationPlant RootsReproducibility of ResultsIndoleacetic AcidsMicroRNAsPlant Proteins

Identifiers

PMID25941314
PMCPMC4741323
OpenAlexW2136196762

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.