Evidence map›Paper›PMID 25941219›Full record

ArticleAntimicrobial agents and chemotherapy2015

Metronidazole- and carbapenem-resistant bacteroides thetaiotaomicron isolated in Rochester, Minnesota, in 2014.

Sapna P Sadarangani, Scott A Cunningham, Patricio R Jeraldo, John W Wilson, Reeti Khare, Robin Patel

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 43 citations in OpenAlex.

  1. A not too Fragile Bacteroides.Journal of community hospital internal medicine perspectives · 2025
    Article
  2. Otogenic Cerebellar Abscess with Polymicrobial Anaerobic Infection in a Young Female- A Rare Presentation.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024
    Article
  3. Fifty years devoted to anaerobes: historical, lessons, and highlights.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024
    Review
  4. AmidinoquinoxalineRSC advances · 2023
    Article
  5. Review
  6. Article
  7. Article
  8. Septic arthritis caused by Bacteroides thetaiotaomicrom: A case report and review.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2021
    Article
  9. The Antimicrobial Susceptibility ofAntibiotics (Basel, Switzerland) · 2021
    Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Clinical and Microbiological Characteristics ofJournal of bone and joint infection · 2017
    Article
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sapna P SadaranganiDivision of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, USA.
Scott A CunninghamDivision of Clinical Microbiology, Mayo Clinic, Rochester, Minnesota, USA.
Patricio R JeraldoDepartment of Surgery, Mayo Clinic, Rochester, Minnesota, USA Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.ORCID http://orcid.org/0000-0003-0282-4217
John W WilsonDivision of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, USA.
Reeti KhareDivision of Clinical Microbiology, Mayo Clinic, Rochester, Minnesota, USA.
Robin PatelDivision of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, USA Division of Clinical Microbiology, Mayo Clinic, Rochester, Minnesota, USA patel.robin@mayo.edu.
Mayo Clinic · USMayo Clinic in Florida · US

Funding

The Electricidal Effect, a Novel Anti-Biofilm StrategyR01AI091594 · NIAID · MAYO CLINIC ROCHESTER · PI Haluk Beyenal, Robin Patel · 2011 to 2026
$5.5M
Molecular Detection of Biofilms on Hip and Knee ImplantsR01AR056647 · NIAMS · MAYO CLINIC ROCHESTER · PI PATEL, ROBIN · 2009 to 2020
$4.5M
Microbial Metabolic Toxicity Drives Colon CancerR01CA179243 · NCI · MAYO CLINIC ROCHESTER · PI CHIA, NICHOLAS · 2014 to 2018
$2.0M
NCI NIH HHS R01 CA179243NIAID NIH HHS R01 AI091594NIAMS NIH HHS R01 AR056647
6 · The paper itself

Abstract

Emerging antimicrobial resistance in members of the Bacteroides fragilis group is a concern in clinical medicine. Although metronidazole and carbapenem resistance have been reported in Bacteroides thetaiotaomicron, a member of the B. fragilis group, they have not, to the best of our knowledge, been reported together in the same B. thetaiotaomicron isolate. Herein, we report isolation of piperacillin-tazobactam-, metronidazole-, clindamycin-, ertapenem-, and meropenem-resistant B. thetaiotaomicron from a patient with postoperative intra-abdominal abscess and empyema. Whole-genome sequencing demonstrated the presence of nimD with at least a portion of IS1169 upstream, a second putative nim gene, two β-lactamase genes (one of which has not been previously reported), two tetX genes, tetQ, ermF, two cat genes, and a number of efflux pumps. This report highlights emerging antimicrobial resistance in B. thetaiotaomicron and the importance of identification and antimicrobial susceptibility testing of selected anaerobic bacteria.

Indexed as

AbscessAdultAnti-Bacterial AgentsBacterial ProteinsBacteroidesBacteroides Infectionsbeta-LactamasesCarbapenemsDiverticulitis, ColonicDNA, BacterialDrug Resistance, BacterialEmpyemaGenome, BacterialHumansMaleMetronidazoleAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasesCarbapenemsDNA, BacterialMetronidazoleNimD protein, Bacteroides fragilis

Identifiers

PMID25941219
PMCPMC4468676
OpenAlexW1820587150

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.