Evidence map›Paper›PMID 25941207›Full record

ArticleNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2016

An Adolescent Substance Prevention Model Blocks the Effect of CHRNA5 Genotype on Smoking During High School.

David J Vandenbergh, Gabriel L Schlomer, H Harrington Cleveland, Alisa E Schink, Kerry L Hair, Mark E Feinberg, Jenae M Neiderhiser, Mark T Greenberg, Richard L Spoth, Cleve Redmond

Abstract read
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In one paragraph

Article in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. A Genetic Epidemiological Mega Analysis of Smoking Initiation in Adolescents.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2017
    Pooled it
  3. Little Evidence of Modified Genetic Effect of rs16969968 on Heavy Smoking Based on Age of Onset of Smoking.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2021
    Article
  4. Romantic Partner Alcohol Misuse Interacts withJournal of contemporary criminal justice · 2019
    Article
  5. Article
  6. Critical Issues in the Inclusion of Genetic and Epigenetic Information in Prevention and Intervention Trials.Prevention science : the official journal of the Society for Prevention Research · 2018
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

David J VandenberghDepartment of Biobehavioral Health, Penn State University, University Park, PA; Institute for the Neurosciences, Penn State University, University Park, PA; Molecular Cellular and Integrative Biosciences Program, Penn State University, University Park, PA; djv4@psu.edu.
Gabriel L SchlomerDepartment of Biobehavioral Health, Penn State University, University Park, PA; Department of Human Development and Family Studies, Penn State University, University Park, PA;
H Harrington ClevelandDepartment of Human Development and Family Studies, Penn State University, University Park, PA;
Alisa E SchinkMolecular Cellular and Integrative Biosciences Program, Penn State University, University Park, PA;
Kerry L HairDepartment of Biobehavioral Health, Penn State University, University Park, PA; Department of Human Development and Family Studies, Penn State University, University Park, PA;
Mark E FeinbergBennett Pierce Prevention Research Center, Penn State University, University Park, PA;
Jenae M NeiderhiserDepartment of Psychology, Penn State University, University Park, PA;
Mark T GreenbergDepartment of Human Development and Family Studies, Penn State University, University Park, PA; Bennett Pierce Prevention Research Center, Penn State University, University Park, PA;
Richard L SpothPartnerships in Prevention Science Institute, Iowa State University, Ames, IA.
Cleve RedmondPartnerships in Prevention Science Institute, Iowa State University, Ames, IA.

Funding

Partnership Model for Diffusion of Proven PreventionR01DA013709 · NIDA · IOWA STATE UNIVERSITY · PI SPOTH, RICHARD · 2002 to 2017
$35.0M
Implications of Genetic Variance for Substance Use Interventions in AdolescenceR01DA030389 · NIDA · PENNSYLVANIA STATE UNIVERSITY, THE · PI CLEVELAND, HOBART HARRINGTON, VANDENBERGH, DAVID J · 2011 to 2014
$2.2M
NIDA NIH HHS DA013709NIDA NIH HHS DA030389NIDA NIH HHS R01 DA013709NIDA NIH HHS R01 DA030389
6 · The paper itself

Abstract

introductionPrevention intervention programs reduce substance use, including smoking, but not all individuals respond. We tested whether response to a substance use prevention/intervention program varies based upon a set of five markers (rs16969968, rs1948, rs578776, rs588765, and rs684513) within the cluster of nicotinic acetylcholine receptor subunit genes (CHRNA5/A3/B4).

methodsParticipants (N = 424) were randomly assigned to either control condition, or a family-based intervention in grade 6 and a school-based drug preventive intervention in grade 7. Smoking in the past month was assessed in grades 9-12 using a four-point scale (0 = never smoked, 1 = smoked but not in last month, 2 = one or a few times, 3 = about once a week or more).

resultsThere was a main effect of both the intervention (b = -0.24, P < .05) and genotype at rs16969968 (b = 0.14, P < .05) on high school smoking. Using dummy coding to allow for nonlinear effects, individuals with the A/A genotype smoked more often than those with G/G (b = 0.33, P < .05). A genotype × intervention effect was found with reduced smoking among those with A/A and G/A genotypes to levels similar to those with the G/G genotype (G/G vs. A/A: b = -0.67, P < .05; A/G vs. A/A: b = -0.61, P < .05; G/G vs. A/G ns). Results were nonsignificant for the other four markers.

conclusionsPreventive interventions can reduce the genetic risk for smoking from rs16969968.

Indexed as

GenotypeSchoolsSmoking PreventionAdolescentAdolescent BehaviorFemaleHumansLongitudinal StudiesMaleNerve Tissue ProteinsPolymorphism, Single NucleotideReceptors, NicotinicRisk FactorsSmokingStudentsCHRNA5 protein, humanNerve Tissue ProteinsReceptors, Nicotinic

Identifiers

PMID25941207
PMCPMC4723675

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.