Evidence map›Paper›PMID 25941056›Full record

ArticleJournal of paediatrics and child health2015

Candida species bloodstream infections in hospitalised children: A 10-year experience.

Shannon Chan, Elizabeth D Baley, Jobayer Hossain, M Cecilia Di Pentima

Abstract read
In one paragraph

Article in Journal of paediatrics and child health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Epidemiology and associated risk factors for candidemia in a Canadian tertiary paediatric hospital: An 11-year review.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2023
    Article
  3. Frontiers in cellular and infection microbiology · 2023
    Review
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Shannon ChanDepartment of Pediatric & Pharmacy, Alfred I. duPont Hospital for Children, Wilmington, Delaware, United States.
Elizabeth D BaleyDepartment of Pharmacy, Cincinnatti Children's Hospital, Cincinnati, Ohio, United States.
Jobayer HossainNemours, Department of Biomedical Research, Wilmington, Delaware, United States.
M Cecilia Di PentimaDepartment of Pediatrics, Vanderbilt University, Nashville, Tennessee, United States.

Funding

Subproject Title: Clinical Research Education, Mentoring and Career Development CoreU54GM104941 · NIGMS · UNIVERSITY OF DELAWARE · PI Gregory E Hicks · 2013 to 2026
$60.5M
LCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI MEINZEN-DERR, JAREEN, STRAWN, JEFFREY ROBERT · 2015 to 2024
$37.5M
NCATS NIH HHS UL1 TR001425NIGMS NIH HHS U54 GM104941
6 · The paper itself

Abstract

In a 10-year retrospective study we assessed the epidemiology of candidemia and the association between the presence and removal of indwelling central venous catheters, antifungal use and clinical outcomes among hospitalised children. Demographic and clinical information were retrieved from the electronic medical records. One hundred six episodes of candidemia were identified in 83 unique patients. Candida parapsilosis was the most prevalent (52%) species, followed by C. albicans (25%). Non-oncologic children receiving fluconazole within 30 days of developing candidemia were most likely to develop C. parapsilosis infection (40%, P = 0.006), independent of total parenteral nutrition (odds ratio (OR) 2.5, 95% confidence interval (CI): 0.6-11, P = 0.3). Crude mortality rate was 12% and significantly higher for children less than 2 years (OR: 6.7, 95% CI: 1.9-23, P = 0.003), and those infected with C. lusitaniae (OR: 9, 95% CI: 1.6-51, P = 0.02). The aggregate use of antifungal agents decreased overtime (χ(2) : 16.7, P < 0.0001). Fluconazole remained the most common antifungal agent used during the study.

Indexed as

CandidaCandidemiaChildChild, HospitalizedChild, PreschoolCross InfectionFemaleHumansMaleMedical AuditPennsylvaniaRetrospective StudiesCandida spp.candidemiapaediatrics

Identifiers

PMID25941056
PMCPMC5646212

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.