ArticleScientific reports2015
The Tomato yellow leaf curl virus V2 protein forms aggregates depending on the cytoskeleton integrity and binds viral genomic DNA.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- The Tomato Transcription Factor RAV Affects the Systemic Infection of TYLCV by Interacting With V2.Molecular plant pathology · 2026Article
- Resistance gene Ty-1 restricts TYLCV infection in tomato by increasing RNA silencing.Virology journal · 2024Article
- Phylogeographic analysis ofThe Journal of general virology · 2024Article
- Reassortments in single-stranded DNA multipartite viruses: Confronting expectations based on molecular constraints with field observations.Virus evolution · 2024Review
- Review
- Role of Plant Virus Movement Proteins in Suppression of Host RNAi Defense.International journal of molecular sciences · 2023Review
- Functional Analysis of V2 Protein of Beet Curly Top Iran Virus.Plants (Basel, Switzerland) · 2022Article
- Translation initiation landscape profiling reveals hidden open-reading frames required for the pathogenesis of tomato yellow leaf curl Thailand virus.The Plant cell · 2022Article
- Host GRXC6 restricts Tomato yellow leaf curl virus infection by inhibiting the nuclear export of the V2 protein.PLoS pathogens · 2021Article
- Tomato Yellow Leaf Curl Virus V2 Protein Plays a Critical Role in the Nuclear Export of V1 Protein and Viral Systemic Infection.Frontiers in microbiology · 2020Article
- RepA Promotes the Nucleolar Exclusion of the V2 Protein of Mulberry Mosaic Dwarf-Associated Virus.Frontiers in microbiology · 2020Article
- Characterization of Curtovirus V2 Protein, a Functional Homolog of Begomovirus V2.Frontiers in plant science · 2020Article
- Plant Antiviral Immunity Against Geminiviruses and Viral Counter-Defense for Survival.Frontiers in microbiology · 2019Review
- Single amino acid in V2 encoded by TYLCV is responsible for its self-interaction, aggregates and pathogenicity.Scientific reports · 2018Article
- AV2 protein of tomato leaf curl Palampur virus promotes systemic necrosis in Nicotiana benthamiana and interacts with host Catalase2.Scientific reports · 2018Article
- Identification of host cellular targets of AC4 and AV2 proteins of tomato leaf curl palampur virus and their sub-cellular localization studies.Virusdisease · 2017Article
- Tomato plant cell death induced by inhibition of HSP90 is alleviated by Tomato yellow leaf curl virus infection.Molecular plant pathology · 2016Article
- Tomato yellow leaf curl virus infection mitigates the heat stress response of plants grown at high temperatures.Scientific reports · 2016Article
- Insights Into Virus-Encoded RNA Silencing Suppressors Across Viral Families: A Focus on Viruses Infecting Solanaceae Crops.Physiologia plantarumReview
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6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The spread of Tomato yellow leaf curl virus (TYLCV) was accompanied by the formation of coat protein (CP) aggregates of increasing size in the cytoplasm and nucleus of infected tomato (Solanum lycopersicum) cells. In order to better understand the TYLCV-host interaction, we investigated the properties and the subcellular accumulation pattern of the non-structural viral protein V2. CP and V2 are the only sense-oriented genes on the virus circular single-stranded DNA genome. Similar to CP, V2 localized to cytoplasmic aggregates of increasing size and as infection progressed was also found in nuclei, where it co-localized with CP. V2 was associated with viral genomic DNA molecules, suggesting that V2 functions as a DNA shuttling protein. The formation and the 26S proteasome-mediated degradation of V2 aggregates were dependent on the integrity of the actin and microtubule cytoskeleton. We propose that the cytoskeleton-dependent formation and growth of V2 aggregates play an important role during TYLCV infection, and that microtubules and actin filaments are important for the delivery of V2 to the 26S proteasome.
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