ArticleAge (Dordrecht, Netherlands)2015
Strength training-induced responses in older adults: attenuation of descending neural drive with age.
Article in Age (Dordrecht, Netherlands), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Age-Related Differences in Corticospinal Function and Muscle Strength: A Systematic Review and Meta-Analysis.The European journal of neuroscience · 2026Pooled it
- Trial
- Maximal strength training in patients with inflammatory rheumatic disease: implications for physical function and quality of life.European journal of applied physiology · 2022Trial
- Age-related differences in corticospinal and reticulospinal adaptations to short-term strength training.European journal of applied physiology · 2026Article
- Load- and velocity-specific adaptations to lower-body maximal strength training (MST), hypertrophy training (HT) and explosive strength training (EST).European journal of applied physiology · 2026Article
- Heavy Strength Training in Older Adults: Implications for Health, Disease and Physical Performance.Journal of cachexia, sarcopenia and muscle · 2025Review
- Kefir and healthy aging: revealing thematic gaps through AI-assisted screening and semantic evidence mapping.Frontiers in aging · 2025Article
- Effects of Explosive vs. Strength Resistance Training on Plantar Flexor Neuromuscular and Functional Capacities in Institutionalized Older Adults: A Randomized Controlled Trial.Journal of functional morphology and kinesiology · 2024Article
- One Year of Heavy Resistance Training Modifies Muscle Fiber Characteristics in the Elderly.Sports medicine international open · 2024Article
- The impact of life-long strength versus endurance training on muscle fiber morphology and phenotype composition in older men.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Relative Neuroadaptive Effect of Resistance Training along the Descending Neuroaxis in Older Adults.Brain sciences · 2023Review
- Myokine Response to Blood-Flow Restricted Resistance Exercise in Younger and Older Males in an Untrained and Resistance-Trained State: A Pilot Study.Journal of science in sport and exercise · 2022Article
- Responses to Maximal Strength Training in Different Age and Gender Groups.Frontiers in physiology · 2021Article
- Menthol-induced cutaneous stimulation combined with self-paced walking training improves knee extension performance in untrained older healthy females.Journal of physical therapy science · 2020Article
- Corticospinal Control of Human Locomotion as a New Determinant of Age-Related Sarcopenia: An Exploratory Study.Journal of clinical medicine · 2020Article
- Structural and Functional Changes in the Coupling of Fascial Tissue, Skeletal Muscle, and Nerves During Aging.Frontiers in physiology · 2020Review
- Eight-Week Low-Intensity Squat Training at Slow Speed Simultaneously Improves Knee and Hip Flexion and Extension Strength.Frontiers in physiology · 2020Article
- Maximal strength training-induced improvements in forearm work efficiency are associated with reduced blood flow.American journal of physiology. Heart and circulatory physiology · 2018Article
- Aging and Strength Training Influence Knee Extensor Intermuscular Coherence During Low- and High-Force Isometric Contractions.Frontiers in physiology · 2018Article
- Moderate-Load Muscular Endurance Strength Training Did Not Improve Peak Power or Functional Capacity in Older Men and Women.Frontiers in physiology · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although reductions in resting H-reflex responses and maximal firing frequency suggest that reduced efferent drive may limit muscle strength in elderly, there are currently no reports of V-wave measurements in elderly, reflecting the magnitude of efferent output to the muscle during maximal contraction. Furthermore, it is uncertain whether potential age-related neural deficiencies can be restored by resistance training. We assessed evoked reflex recordings in the triceps surae muscles during rest and maximal voluntary contraction (MVC), rate of force development (RFD), and muscle mass in seven elderly (74 ± 6 years) males before and after 8 weeks of heavy resistance training, contrasted by seven young (24 ± 4 years) male controls. At baseline, m. soleus (SOL) V/M ratio (0.124 ± 0.082 vs. 0.465 ± 0.197, p < 0.05) and H/M ratio (0.379 ± 0.044 vs. 0.486 ± 0.101 p = 0.07) were attenuated in elderly compared to young. Also, SOL H-reflex latency (33.29 ± 2.41 vs. 30.29 ± 0.67 ms, p < 0.05) was longer in elderly. The reduced neural drive was, despite similar leg muscle mass (10.7 ± 1.2 vs. 11.5 ± 1.4 kg), mirrored by lower MVC (158 ± 48 vs. 240 ± 54 Nm, p < 0.05) and RFD (294 ± 126 vs. 533 ± 123 Nm s(-1), p < 0.05) in elderly. In response to training SOL V/M ratio (0.184 ± 0.092, p < 0.05) increased in the elderly, yet only to a level ~40 % of the young. This was accompanied by increased MVC (190 ± 70 Nm, p < 0.05) and RFD (401 ± 147 Nm[Symbol: see text]s(-1), p < 0.05) to levels of ~80 % and ~75 % of the young. H/M ratio remained unchanged. These findings suggest that changes in supraspinal activation play a significant role in the age-related changes in muscle strength. Furthermore, this motor system impairment can to some extent be improved by heavy resistance training.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.