ArticleThe British journal of nutrition2015
Placental amino acid transport may be regulated by maternal vitamin D and vitamin D-binding protein: results from the Southampton Women's Survey.
Article in The British journal of nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Vitamin D levels in early and middle pregnancy and preeclampsia: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- The Gestational Effects of Maternal Bone Marker Molecules on Fetal Growth, Metabolism and Long-Term Metabolic Health: A Systematic Review.International journal of molecular sciences · 2022Pooled it
- Maternal and Fetal Genetic Variation in Vitamin D Metabolism and Umbilical Cord Blood 25-Hydroxyvitamin D.The Journal of clinical endocrinology and metabolism · 2022Pooled it
- Trial
- Trial
- Vitamin D supports activated CD4Frontiers in immunology · 2026Article
- Vitamin D and Chronic Disorders: A Review of Metabolic and Cardiovascular Diseases.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Associations Between Prenatal Vitamin D and Placental Gene Expression.The Journal of nutrition · 2024Article
- Associations Between Prenatal Vitamin D and Placental Gene Expression.bioRxiv : the preprint server for biology · 2024Article
- Effects of Vitamin D on Fertility, Pregnancy and Polycystic Ovary Syndrome-A Review.Nutrients · 2022Review
- Vitamin D stimulates placental L-type amino acid transporter 1 (LAT1) in preeclampsia.Scientific reports · 2022Article
- Placental uptake and metabolism of 25(OH)vitamin D determine its activity within the fetoplacental unit.eLife · 2022Article
- Epigenetic regulation of bone mass.Best practice & research. Clinical endocrinology & metabolism · 2022Review
- Article
- Investigating a suitable model for the study of vitamin D mediated regulation of human placental gene expression.The Journal of steroid biochemistry and molecular biology · 2020Article
- Clinical Usefulness of Bioavailable Vitamin D and Impact ofInternational journal of endocrinology · 2019Article
- A systems perspective on placental amino acid transport.The Journal of physiology · 2018Review
- In utero exposure to extra vitamin D from food fortification and the risk of subsequent development of gestational diabetes: the D-tect study.Nutrition journal · 2018Article
- Trajectory of vitamin D status during pregnancy in relation to neonatal birth size and fetal survival: a prospective cohort study.BMC pregnancy and childbirth · 2018Article
- Deconvoluting the Biological Roles of Vitamin D-Binding Protein During Pregnancy: A Both Clinical and Theoretical Challenge.Frontiers in endocrinology · 2018Review
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
Both maternal 25-hydroxyvitamin D (25(OH)D) concentrations during pregnancy and placental amino acid transporter gene expression have been associated with development of the offspring in terms of body composition and bone structure. Several amino acid transporter genes have vitamin D response elements in their promoters suggesting the possible linkage of these two mechanisms. We aimed to establish whether maternal 25(OH)D and vitamin D-binding protein (VDBP) levels relate to expression of placental amino acid transporters. RNA was extracted from 102 placental samples collected in the Southampton Women's Survey, and gene expression was analysed using quantitative real-time PCR. Gene expression data were normalised to the geometric mean of three housekeeping genes, and related to maternal factors and childhood body composition. Maternal serum 25(OH)D and VDBP levels were measured by radioimmunoassay. Maternal 25(OH)D and VDBP levels were positively associated with placental expression of specific genes involved in amino acid transport. Maternal 25(OH)D and VDBP concentrations were correlated with the expression of specific placental amino acid transporters, and thus may be involved in the regulation of amino acid transfer to the fetus. The positive correlation of VDBP levels and placental transporter expression suggests that delivery of vitamin D to the placenta may be important. This exploratory study identifies placental amino acid transporters which may be altered in response to modifiable maternal factors and provides a basis for further studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.