ArticleThe Journal of thoracic and cardiovascular surgery2015
Quantifying "normalized" regional left ventricular contractile function in ischemic coronary artery disease.
Article in The Journal of thoracic and cardiovascular surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 9 citations in OpenAlex.
- Trial
- Topographic mapping of left ventricular regional contractile injury in ischemic mitral regurgitation.The Journal of thoracic and cardiovascular surgery · 2017Article
- Echocardiographic assessment of myocardial ischemia.Annals of translational medicine · 2016Review
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectiveWhen significant coronary lesions are identified by angiography, regional left ventricular (LV) contractile function often plays a role in determining candidacy for revascularization. To improve on current subjective and nonquantitative metrics of regional LV function, we tested a z-score "normalization" of regional strain information quantified from clinically acquired high-resolution LV geometric datasets.
methodsTest subjects (n = 120) underwent cardiac MRI with multiple 3-dimensional strain parameters calculated from tissue tag-plane displacement data. Sixty healthy volunteers contributed strain parameter data at each of 15,300 LV grid points, to form a normal human strain database. Point-specific database comparisons were made in 60 patients who had documented coronary artery disease (CAD), by angiography. Patient-specific, color-coded 3-dimensional LV maps of z-score-normalized contractile function were generated.
resultsBlinded clinical review indicated that 55% (33 of 60) of the patients with CAD had significant regional contractile abnormalities by 1 of 3 "gold-standard" criteria: (1) Q waves on electrocardiography (ECG); (2) infarct on radionuclide single-photon emission computed tomography (SPECT); or (3) akinesia or dyskinesia on echocardiography. Consistency among all gold-standard metrics was found for only 19% (6 of 31) of patients with CAD who had ≥2 available metrics. Blinded MRI-based, multiparametric, strain z-score localization of contractile abnormalities was accurate in 89% (ECG), 97% (SPECT), and 95% (echocardiography).
conclusionsNonsubjective normalization of regional LV contractile function by z-score calculation from a normal human strain database can localize and quantitatively display regional wall motion abnormalities in patients with CAD. This high-resolution localization of regional wall motion abnormalities may help improve the accuracy of therapeutic intervention in patients who have CAD.
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