Evidence map›Paper›PMID 25940252›Full record

ReviewChest2015

Antimicrobial resistance in hospital-acquired gram-negative bacterial infections.

Borna Mehrad, Nina M Clark, George G Zhanel, Joseph P Lynch

Open access · bronzeAbstract readReview
In one paragraph

Review in Chest, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed
4.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 218 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Antimicrobial agents and chemotherapy · 2020
    Trial
  4. Article
  5. Article
  6. Article
  7. Article
  8. Observational
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. IsLife (Basel, Switzerland) · 2025
    Article
  18. Article
  19. Article
  20. Article

36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Borna MehradDivision of Pulmonary and Critical Care Medicine and The Carter Center for Immunology, University of Virginia, Charlottesville, VA.
Nina M ClarkDivision of Infectious Diseases, Department of Medicine, Loyola University, Maywood, IL.
George G ZhanelDepartment of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada.
Joseph P LynchDivision of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA. Electronic address: jplynch@mednet.ucla.edu.
Loyola University Chicago · USUniversity of California, Los Angeles · USUniversity of Manitoba · CAUniversity of Virginia · US

Funding

Fibrocytes in human pulmonary fibrosisR01HL098329 · NHLBI · UNIVERSITY OF VIRGINIA · PI MEHRAD, BORNA, ROSE, C EDWARD · 2011 to 2015
$2.7M
Fibrocytes in the Pathogenesis of Sickle Cell Lung DiseaseR01HL098526 · NHLBI · UNIVERSITY OF VIRGINIA · PI ROSE, C EDWARD · 2010 to 2013
$2.0M
Neutrophils and adaptive immunity against invasive aspergillosisR21AI117397 · NIAID · UNIVERSITY OF VIRGINIA · PI MEHRAD, BORNA · 2015 to 2016
$435k
NHLBI NIH HHS HL09832NHLBI NIH HHS HL098526NHLBI NIH HHS R01 HL098526
6 · The paper itself

Abstract

Aerobic gram-negative bacilli, including the family of Enterobacteriaceae and non-lactose fermenting bacteria such as Pseudomonas and Acinetobacter species, are major causes of hospital-acquired infections. The rate of antibiotic resistance among these pathogens has accelerated dramatically in recent years and has reached pandemic scale. It is no longer uncommon to encounter gram-negative infections that are untreatable using conventional antibiotics in hospitalized patients. In this review, we provide a summary of the major classes of gram-negative bacilli and their key mechanisms of antimicrobial resistance, discuss approaches to the treatment of these difficult infections, and outline methods to slow the further spread of resistance mechanisms.

Indexed as

Drug Resistance, BacterialCross InfectionGram-Negative Bacterial InfectionsHumans

Identifiers

PMID25940252
PMCPMC4420185
OpenAlexW1618462379

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.