Evidence map›Paper›PMID 25940151›Full record

Trial reportJournal of gastroenterology2016

Proton pump inhibitor after endoscopic resection for esophageal squamous cell cancer: multicenter prospective randomized controlled trial.

N Kakushima, K Hori, H Ono, T Horimatsu, N Uedo, K Ohata, H Doyama, K Kaneko, I Oda, T Hikichi and 10 more

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. World journal of gastroenterology · 2024
    Review
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 14 institutions in 1 country.

N KakushimaDivision of Endoscopy, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi, Suntougun, Shizuoka, 4118777, Japan. kakushin-tky@umin.ac.jp.
K HoriKyoto University Graduate School of Medicine, Kyoto, Japan.
H OnoDivision of Endoscopy, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi, Suntougun, Shizuoka, 4118777, Japan.
T HorimatsuKyoto University Graduate School of Medicine, Kyoto, Japan.
N UedoOsaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan.
K OhataNTT Medical Center Tokyo, Tokyo, Japan.
H DoyamaIshikawa Prefectural Central Hospital, Kanazawa, Ishikawa, Japan.
K KanekoNational Cancer Center East, Chiba, Japan.
I OdaNational Cancer Center, Tokyo, Japan.
T HikichiFukushima Medical University, Fukushima, Japan.
Y KawaharaOkayama University Hospital, Okayama, Japan.
K NiimiThe University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Y TakakiFukuoka University Chikushi Hospital, Fukuoka, Japan.
M MizunoHiroshima City Hospital, Hiroshima, Japan.
S YazumiKitano General Hospital, Osaka, Japan.
A HosokawaToyama University Hospital, Toyama, Japan.
A ImagawaMitoyo General Hospital, Kanonji, Kagawa, Japan.
M NiimiKyoto University Graduate School of Medicine, Kyoto, Japan.
K YoshimuraKobe University School of Medicine, Kobe, Japan.
M MutoKyoto University Graduate School of Medicine, Kyoto, Japan.
Kyoto University · JPFukuoka University Hospital · JPFukushima Medical University · JPIshikawa Prefectural Central Hospital · JPKitano Hospital · JPKobe University · JPMito Saiseikai General Hospital · JPNational Cancer Center Hospital East · JPNTT Medical Center · JPOkayama University Hospital · JPOsaka Medical Center for Cancer and Cardiovascular Diseases · JPShizuoka Cancer Center · JPThe University of Tokyo · JPToyama University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWhether proton pump inhibitors (PPIs) relieve heartburn or precordial pain after endoscopic resection (ER) for esophageal squamous cell carcinoma (ESCC) remains unclear. The aim of this study was to investigate the efficacy of PPI therapy for these symptoms after ER for ESCC.

methodsWe conducted a multicenter prospective randomized controlled trial among 15 hospitals in Japan. In total, 229 patients with cT1a ESCC were randomly assigned to receive PPI therapy for 5 weeks after ER (the PPI group, n = 115) or follow-up without PPI therapy (the non-PPI group, n = 114). The primary end point was the incidence of gastroesophageal reflux disease (GERD)-like symptoms after ER from a self-reported questionnaire (Frequency Scale for Symptoms of GERD). Secondary end points were ulcer healing rate at 5 weeks, incidence of pain, improvement rate of symptoms in those who started PPI therapy because of GERD-like symptoms in the non-PPI group, and adverse events.

resultsNo significant difference was observed in the incidence of GERD-like symptoms after ER between the non-PPI and PPI groups (30 % vs 34 %, respectively). No significant differences were observed in the ulcer healing rate at 5 weeks (84 % vs 85 %) and incidence of pain within 1 week (36 % vs 45 %). In nine of ten patients (90 %) who started PPI therapy because of GERD-like symptoms in the non-PPI group, PPI administration relieved GERD-like symptoms. No adverse events related to PPI administration were observed.

conclusionPPI therapy is not efficacious in reducing symptoms and did not promote healing of ulcers in patients undergoing ER for ESCC.

Indexed as

AdultAgedCarcinoma, Squamous CellEsophageal DiseasesEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaEsophagoscopyFemaleGastroesophageal RefluxHeartburnHumansMaleMiddle AgedPain MeasurementPostoperative PainProspective StudiesProton Pump InhibitorsEndoscopic resectionEsophageal cancerGastroesophageal reflux diseaseProton pump inhibitorSquamous cell cancer

Identifiers

PMID25940151
OpenAlexW223942651

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.