ReviewCardiovascular journal of Africa
HIV-associated large-vessel vasculopathy: a review of the current and emerging clinicopathological spectrum in vascular surgical practice.
Review in Cardiovascular journal of Africa. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Cerebrospinal fluid proteomics reveals inflammatory activation in aneurysmal subarachnoid hemorrhage irrespective of HIV status.AIDS (London, England) · 2026Observational
- Endovascular Management of Aneurysmal Subarachnoid Hemorrhage in People Living With HIV: Comparable Outcomes in a High-Prevalence Setting.Neurosurgery practice · 2026Article
- Chronic kidney disease induces a distinct lipidomic signature and accelerates atherosclerosis progression in a novel minipig model.Laboratory animal research · 2026Article
- Redefining HIV-associated large-vessel vasculopathy in the antiretroviral therapy era: Multi-detector CT imaging findings and their correlation with intervention and patient outcomes.SA journal of radiology · 2026Article
- Celiac Artery Dissection in an HIV-Positive Patient With Cocaine Use: A Rare Vascular Emergency.Cureus · 2025Article
- Aneurysm formation and postcoiling recurrence in HIV-associated vasculopathy: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- Review
- Premature chondrodermatitis nodularis (adults < 61 years) and infection with human immunodeficiency virus: a matched multi-centre case-control study in North Spain.Postepy dermatologii i alergologii · 2024Article
- Evaluation of aortic wall strength in human immunodeficiency virus associated thoracic ascending aortic aneurysm: a pilot study.Cardiovascular diagnosis and therapy · 2023Article
- Article
- Multiple fusiform and saccular aneurysms in a person living with Human Immunodeficiency Virus.SAGE open medical case reports · 2023Article
- Spectrum of ascending aortic aneurysms at a peri-urban tertiary hospital: an echocardiography-based study.Frontiers in cardiovascular medicine · 2023Article
- Prevalence and risk factors of lower extremity disease in high risk groups in Malawi: a stratified cross-sectional study.BMJ open · 2022Article
- Neurological consequences of neurovascular unit and brain vasculature damages: potential risks for pregnancy infections and COVID-19-babies.The FEBS journal · 2022Review
- Overview of infections as an etiologic factor and complication in patients with vasculitides.Rheumatology international · 2022Review
- Association of HIV Serostatus and Inflammation With Ascending Aortic Size.Journal of the American Heart Association · 2022Article
- Endovascular management of HIV vasculopathy.Journal of clinical imaging science · 2022Article
- Epidemiology and management of aortic disease: aortic aneurysms and acute aortic syndromes.Nature reviews. Cardiology · 2021Review
- More Than Just an Ulcer: A Case of HIV-Associated Iliac Aneurysms Presenting With a Leg Ulcer.Cureus · 2021Article
- A Novel Large-Vessel Arteritis in SARS-CoV-2-Related Multisystem Inflammatory Syndrome in Children (MIS-C).Radiology. Cardiothoracic imaging · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
An established relationship exists between human immunodeficiency virus (HIV) and the vascular system, which is characterised by clinical expressions of aneurysmal and occlusive disease that emanate from a common pathological process. The exact pathogenesis is currently unknown; attempts to implicate opportunistic pathogens have been futile. Theories converge on leucocytoclastic vasculitis with the vaso vasora as the vasculopathic epicentre. It is thought that the virus itself or viral proteins trigger the release of inflammatory mediators that cause endothelial dysfunction and smooth muscle proliferation leading to vascular injury and thrombosis. The beneficial effects of highly active anti-retroviral therapy alter the natural history of the disease profile and promote longevity but are negated by cardiovascular complications. Atherosclerosis is an emerging challenge. Presently patients are managed by standard surgical protocols because of non-existent universal surgical interventional guidelines. Clinical response to treatment is variable and often compounded by complications of graft occlusion, sepsis and poor wound healing. The clinical, imaging and pathological observations position HIV-associated large-vessel vasculopathy as a unique entity. This review highlights the spectrum of HIV-associated large-vessel aneurysmal, occlusive and atherosclerotic disease in vascular surgical practice.
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