ArticleChemical communications (Cambridge, England)2015
Spinach RNA aptamer detects lead(II) with high selectivity.
Article in Chemical communications (Cambridge, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
15 citing papers in PubMed, 68 citations in OpenAlex.
- Live-cell imaging of RNA dynamics using bright and stable fluorescent RNAs.Nature protocols · 2026Review
- Visualizing Diverse RNA Functions in Living Cells With SpinachBio-protocol · 2026Article
- Fluorogenic RNA-Based Biosensors of Small Molecules: Current Developments, Uses, and Perspectives.Biosensors · 2024Review
- A Prebiotic Genetic Nucleotide as an Early Darwinian Ancestor for Pre-RNA Evolution.ACS omega · 2024Article
- Recent Achievements in Electrochemical and Optical Nucleic Acids Based Detection of Metal Ions.Molecules (Basel, Switzerland) · 2022Review
- Single-tube isothermal label-free fluorescent sensor for pathogen detection based on genetic signatures.Frontiers in chemistry · 2022Article
- Programmable RNA detection with a fluorescent RNA aptamer using optimized three-way junction formation.RNA (New York, N.Y.) · 2019Article
- Hachimoji DNA and RNA: A genetic system with eight building blocks.Science (New York, N.Y.) · 2019Article
- Fluorogenic RNA Aptamers: A Nano-platform for Fabrication of Simple and Combinatorial Logic Gates.Nanomaterials (Basel, Switzerland) · 2018Article
- A highly sensitive and selective fluorescent probe without quencher for detection of PbRSC advances · 2018Article
- Structural basis for activation of fluorogenic dyes by an RNA aptamer lacking a G-quadruplex motif.Nature communications · 2018Article
- Light-Up RNA Aptamers and Their Cognate Fluorogens: From Their Development to Their Applications.International journal of molecular sciences · 2017Review
- Modifications of the chromophore of Spinach aptamer based on QM:MM calculations.Journal of molecular modeling · 2017Article
- G Quadruplex in Plants: A Ubiquitous Regulatory Element and Its Biological Relevance.Frontiers in plant science · 2017Review
- Split Spinach Aptamer for Highly Selective Recognition of DNA and RNA at Ambient Temperatures.Chembiochem : a European journal of chemical biology · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Spinach RNA aptamer contains a G-quadruplex motif that serves as a platform for binding and fluorescence activation of a GFP-like fluorophore. Here we show that Pb(2+) induces formation of Spinach's G-quadruplex and activates fluorescence with high selectivity and sensitivity. This device establishes the first example of an RNA-based sensor that provides a simple and inexpensive tool for Pb(2+) detection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.