ArticleThe EMBO journal2015
Adaptation of avian influenza A (H6N1) virus from avian to human receptor-binding preference.
Article in The EMBO journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Analyses of receptor binding specificity of highly pathogenic avian influenza A (H5N1) viruses isolated from felines in South Korea, 2023.Virulence · 2026Article
- Genomic characterization of H6N1 avian influenza viruses from wild birds and domestic ducks in the republic of Korea and Mongolia (2022-2024).Archives of virology · 2026Article
- Whole-genome characterization and antigenic analysis of two distinct duck-origin H6 Subtype avian influenza viruses in China.Virus genes · 2026Article
- A Novel Recombinant Chicken-Derived H6N8 Subtype Avian Influenza Virus Caused Disease in Chickens and Mice.Viruses · 2025Article
- Divergent Avian Influenza H10 Viruses from Sympatric Waterbird Species in Italy: Zoonotic Potential Assessment by Molecular Markers.Microorganisms · 2025Article
- Article
- Cross-Species Transmission Potential of H4 Avian Influenza Viruses in China: Epidemiological and Evolutionary Study.Viruses · 2024Article
- Evolutionary characterization of the establishment of H6 influenza viruses in domestic geese in China: implications for the position of the host in the ecosystem.Virus evolution · 2024Article
- Global distribution, receptor binding, and cross-species transmission of H6 influenza viruses: risks and implications for humans.Journal of virology · 2023Review
- Review
- Molecular modeling and phylogenetic analyses highlight the role of amino acid 347 of the N1 subtype neuraminidase in influenza virus host range and interspecies adaptation.Frontiers in microbiology · 2023Article
- Influenza A (H6N6) viruses isolated from chickens replicate in mice and human lungs without prior adaptation.Journal of virus eradication · 2022Article
- The Genomic Evolution and the Transmission Dynamics of H6N2 Avian Influenza A Viruses in Southern China.Viruses · 2022Article
- Evolutionary pressures rendered by animal husbandry practices for avian influenza viruses to adapt to humans.iScience · 2022Review
- Emerging HxNy Influenza A Viruses.Cold Spring Harbor perspectives in medicine · 2022Review
- Genetic characterization and evolution of H6N6 subtype avian influenza viruses.Frontiers in microbiology · 2022Article
- Characterization of Subtype H6 Avian Influenza A Viruses Isolated From Wild Birds in Poyang Lake, China.Frontiers in veterinary science · 2021Article
- Evolution and pathogenicity of H6 avian influenza viruses isolated from Southern China during 2011 to 2017 in mice and chickens.Scientific reports · 2020Article
- Dominant subtype switch in avian influenza viruses during 2016-2019 in China.Nature communications · 2020Article
- Review
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11 authors.
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Abstract
The receptor-binding specificity of influenza A viruses is a major determinant for the host tropism of the virus, which enables interspecies transmission. In 2013, the first human case of infection with avian influenza A (H6N1) virus was reported in Taiwan. To gather evidence concerning the epidemic potential of H6 subtype viruses, we performed comprehensive analysis of receptor-binding properties of Taiwan-isolated H6 HAs from 1972 to 2013. We propose that the receptor-binding properties of Taiwan-isolated H6 HAs have undergone three major stages: initially avian receptor-binding preference, secondarily obtaining human receptor-binding capacity, and recently human receptor-binding preference, which has been confirmed by receptor-binding assessment of three representative virus isolates. Mutagenesis work revealed that E190V and G228S substitutions are important to acquire the human receptor-binding capacity, and the P186L substitution could reduce the binding to avian receptor. Further structural analysis revealed how the P186L substitution in the receptor-binding site of HA determines the receptor-binding preference change. We conclude that the human-infecting H6N1 evolved into a human receptor preference.
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