ArticleJournal of biomedical materials research. Part B, Applied biomaterials2016
The role of substrate topography on the cellular uptake of nanoparticles.
Article in Journal of biomedical materials research. Part B, Applied biomaterials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Hybrid fibrous architectures-mediated gene transfer by pDNA nanoparticles into macrophages.Heliyon · 2024Article
- The Effect of Substrate Properties on Cellular Behavior and Nanoparticle Uptake in Human Fibroblasts and Epithelial Cells.Nanomaterials (Basel, Switzerland) · 2024Article
- Regulation of cell fate by cell imprinting approach in vitro.BioImpacts : BI · 2024Review
- Assessing hypoxic damage to placental trophoblasts by measuring membrane viscosity of extracellular vesicles.Placenta · 2022Article
- Endocytosis of abiotic nanomaterials and nanobiovectors: Inhibition of membrane trafficking.Nano today · 2021Review
- Effects of Co-Solvent Nature and Acid Concentration in the Size and Morphology of Wrinkled Mesoporous Silica Nanoparticles for Drug Delivery Applications.Molecules (Basel, Switzerland) · 2021Article
- Particle Stiffness and Surface Topography Determine Macrophage-Mediated Removal of Surface Adsorbed Particles.Advanced healthcare materials · 2021Article
- Improving mechanical and antibacterial properties of PMMA via polyblend electrospinning with silk fibroin and polyethyleneimine towards dental applications.Bioactive materials · 2020Article
- Biomimetic polycaprolactone-chitosan nanofibrous substrate influenced cell cycle and ECM secretion affect cellular uptake of nanoclusters.Bioactive materials · 2019Article
- Identification of Key Signaling Pathways Orchestrating Substrate Topography Directed Osteogenic Differentiation Through High-Throughput siRNA Screening.Scientific reports · 2019Article
- Nanoparticles of Titanium and Zinc Oxides as Novel Agents in Tumor Treatment: a Review.Nanoscale research letters · 2017Article
- 3D Near-Field Electrospinning of Biomaterial Microfibers with Potential for Blended Microfiber-Cell-Loaded Gel Composite Structures.Advanced healthcare materials · 2017Article
- Carbon Nanotubes Induced Fibrogenesis on Nanostructured Substrates.Environmental science. Nano · 2017Article
- Biophysical Regulation of Cell Behavior-Cross Talk between Substrate Stiffness and Nanotopography.Engineering (Beijing, China) · 2017Article
- The effects of collagen-rich extracellular matrix on the intracellular delivery of glycol chitosan nanoparticles in human lung fibroblasts.International journal of nanomedicine · 2017Article
- Nanotopographical Modulation of Cell Function through Nuclear Deformation.ACS applied materials & interfaces · 2016Article
- Physical Principles of Nanoparticle Cellular Endocytosis.ACS nano · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Improving targeting efficacy has been a central focus of the studies on nanoparticle (NP)-based drug delivery nanocarriers over the past decades. As cells actively sense and respond to the local physical environments, not only the NP design (e.g., size, shape, ligand density, etc.) but also the cell mechanics (e.g., stiffness, spreading, expressed receptors, etc.) affect the cellular uptake efficiency. While much work has been done to elucidate the roles of NP design for cells seeded on a flat tissue culture surface, how the local physical environments of cells mediate uptake of NPs remains unexplored, despite the widely known effect of local physical environments on cellular responses in vitro and disease states in vivo. Here, we report the active responses of human osteosarcoma cells to fibrous substrate topographies and the subsequent changes in the cellular uptake of NPs. Our experiments demonstrate that surface topography modulates cellular uptake efficacy by mediating cell spreading and membrane mechanics. The findings provide a concrete example of the regulative role of the physical environments of cells on cellular uptake of NPs, therefore advancing the rational design of NPs for enhanced drug delivery in targeted cancer therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.