ArticleLiver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society2015
Declining liver graft quality threatens the future of liver transplantation in the United States.
Article in Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07651748 (Secretin Therapy During Ex-Situ Normothermic Liver Machine Perfusion), which is not on this map. Cited by 58 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Secretin Therapy During Ex-Situ Normothermic Liver Machine Perfusion: A Critical Factor for Restoration of Bile Duct Physiology and the Protective "Bicarbonate Umbrella"
Who cites it
58 citing papers in PubMed, 130 citations in OpenAlex.
- The impact of post-transplant diabetes mellitus on liver transplant outcomes.Clinical transplantation · 2019Trial
- Evaluation of Living Donor Liver Transplantation in Germany: Opportunities for Expanding the Donor Pool.Zeitschrift fur Gastroenterologie · 2026Article
- Protective strategies and therapeutic interventions for ischemia-reperfusion injury: potential applications in normothermic machine perfusion.Annals of medicine and surgery (2012) · 2025Review
- 'Back-to-base' combined hypothermic and normothermic machine perfusion of human donor livers.Nature protocols · 2025Review
- The adverse impact of early postoperative complications after liver transplantation on long-term prognosis in patients with hepatocellular carcinoma.World journal of surgical oncology · 2025Article
- Therapeutic hyperthermia promotes lipid export and HSP70/90 during machine perfusion of human livers.Physiological reports · 2025Article
- Long-term machine perfusion of human split livers: a new model for regenerative and translational research.Nature communications · 2024Review
- Recent Advances in Liver Transplantation for Hepatocellular Carcinoma.Current treatment options in oncology · 2024Review
- Distinctive protein expression in elderly livers in a Sprague-Dawley rat model of normothermic ex vivo liver machine perfusion.European journal of medical research · 2024Article
- A Decade of Liver Transplantation in the United States: Drivers of Discard and Underutilization.Transplantation direct · 2024Article
- Article
- Trends in Survival for Adult Organ Transplantation.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2024Article
- Current Understanding of Marginal Grafts in Liver Transplantation.Aging and disease · 2024Review
- Mesenchymal Stem Cells and Extracellular Vesicles: Therapeutic Potential in Organ Transplantation.Stem cells international · 2024Review
- Changing liver utilization and discard rates in clinical transplantation in the ex-vivo machine preservation era.Frontiers in medical technology · 2023Review
- Liver Machine Perfusion-When Physiopathology Matters.Journal of clinical medicine · 2022Article
- Outcomes after Liver Transplantation with Steatotic Grafts: Redefining Acceptable Cutoffs for Steatotic Grafts.Euroasian journal of hepato-gastroenterology · 2022Article
- Sequential hypothermic and normothermic machine perfusion enables safe transplantation of high-risk donor livers.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022Observational
- Dual Lactate Clearance in the Viability Assessment of Livers Donated After Circulatory Death With Ex Situ Normothermic Machine Perfusion.Transplantation direct · 2021Article
- Early transplantation maximizes survival in severe acute-on-chronic liver failure: Results of a Markov decision process model.JHEP reports : innovation in hepatology · 2021Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
National liver transplantation (LT) volume has declined since 2006, in part because of worsening donor organ quality. Trends that degrade organ quality are expected to continue over the next 2 decades. We used the United Network for Organ Sharing (UNOS) database to inform a 20-year discrete event simulation estimating LT volume from 2010 to 2030. Data to inform the model were obtained from deceased organ donors between 2000 and 2009. If donor liver utilization practices remain constant, utilization will fall from 78% to 44% by 2030, resulting in 2230 fewer LTs. If transplant centers increase their risk tolerance for marginal grafts, utilization would decrease to 48%. The institution of "opt-out" organ donation policies to increase the donor pool would still result in 1380 to 1866 fewer transplants. Ex vivo perfusion techniques that increase the use of marginal donor livers may stabilize LT volume. Otherwise, the number of LTs in the United States will decrease substantially over the next 15 years. In conclusion, the transplant community will need to accept inferior grafts and potentially worse posttransplant outcomes and/or develop new strategies for increasing organ donation and utilization in order to maintain the number of LTs at the current level.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.