Evidence map›Paper›PMID 25939429›Full record

ArticleMammalian genome : official journal of the International Mammalian Genome Society2015

GXD: a community resource of mouse Gene Expression Data.

Constance M Smith, Jacqueline H Finger, Terry F Hayamizu, Ingeborg J McCright, Jingxia Xu, Janan T Eppig, James A Kadin, Joel E Richardson, Martin Ringwald

Abstract read
In one paragraph

Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Bridging mouse and human anatomies; a knowledge-based approach to comparative anatomy for disease model phenotyping.Mammalian genome : official journal of the International Mammalian Genome Society · 2023
    Review
  3. Mouse Genome Informatics (MGI): latest news from MGD and GXD.Mammalian genome : official journal of the International Mammalian Genome Society · 2022
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Noncoding copy-number variations are associated with congenital limb malformation.Genetics in medicine : official journal of the American College of Medical Genetics · 2018
    Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Mouse genome database 2016.Nucleic acids research · 2016
    Article
  17. Mouse anatomy ontologies: enhancements and tools for exploring and integrating biomedical data.Mammalian genome : official journal of the International Mammalian Genome Society · 2015
    Article
  18. Mouse Genome Informatics (MGI): reflecting on 25 years.Mammalian genome : official journal of the International Mammalian Genome Society · 2015
    Review
  19. Orthology for comparative genomics in the mouse genome database.Mammalian genome : official journal of the International Mammalian Genome Society · 2015
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Constance M SmithThe Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Jacqueline H Finger
Terry F Hayamizu
Ingeborg J McCright
Jingxia Xu
Janan T Eppig
James A Kadin
Joel E Richardson
Martin Ringwald

Funding

Shared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI William Carl Skarnes · 1985 to 2026
$61.9M
Technical DevelopmentP41HD062499 · NICHD · JACKSON LABORATORY · PI MARTIN RINGWALD · 2011 to 2026
$37.3M
NCI NIH HHS P30 CA034196NICHD NIH HHS HD062499NICHD NIH HHS P41 HD062499
6 · The paper itself

Abstract

The Gene Expression Database (GXD) is an extensive, easily searchable, and freely available database of mouse gene expression information (www.informatics.jax.org/expression.shtml). GXD was developed to foster progress toward understanding the molecular basis of human development and disease. GXD contains information about when and where genes are expressed in different tissues in the mouse, especially during the embryonic period. GXD collects different types of expression data from wild-type and mutant mice, including RNA in situ hybridization, immunohistochemistry, RT-PCR, and northern and western blot results. The GXD curators read the scientific literature and enter the expression data from those papers into the database. GXD also acquires expression data directly from researchers, including groups doing large-scale expression studies. GXD currently contains nearly 1.5 million expression results for over 13,900 genes. In addition, it has over 265,000 images of expression data, allowing users to retrieve the primary data and interpret it themselves. By being an integral part of the larger Mouse Genome Informatics (MGI) resource, GXD's expression data are combined with other genetic, functional, phenotypic, and disease-oriented data. This allows GXD to provide tools for researchers to evaluate expression data in the larger context, search by a wide variety of biologically and biomedically relevant parameters, and discover new data connections to help in the design of new experiments. Thus, GXD can provide researchers with critical insights into the functions of genes and the molecular mechanisms of development, differentiation, and disease.

Indexed as

Databases, GeneticGenomeUser-Computer InterfaceAnimalsData MiningEmbryo, MammalianGene ExpressionGenetic MarkersHumansInformation DisseminationMiceOrgan SpecificityGenetic Markers

Identifiers

PMID25939429
PMCPMC4534488

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.