Evidence map›Paper›PMID 25939274›Full record

ReviewNature reviews. Neurology2015

FTD and ALS--translating mouse studies into clinical trials.

Lars M Ittner, Glenda M Halliday, Jillian J Kril, Jürgen Götz, John R Hodges, Matthew C Kiernan

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Review
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  9. Review
  10. Article
  11. Article
  12. Neuroinflammation in frontotemporal dementia.Nature reviews. Neurology · 2019
    Review
  13. Review
  14. The Potential of Flavonoids for the Treatment of Neurodegenerative Diseases.International journal of molecular sciences · 2019
    Review
  15. Article
  16. Review
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lars M IttnerDementia Research Unit, School of Medical Sciences, Wallace Wurth Building East, The University of New South Wales, Sydney, NSW 2052, Australia.
Glenda M HallidayThe University of New South Wales and Neuroscience Research Australia, Margarete Ainsworth Building, Barker Street, Sydney, NSW 2031, Australia.
Jillian J KrilDisciplines of Medicine and Pathology, Sydney Medical School, Edward Ford Building A27, The University of Sydney, Sydney, NSW 2006, Australia.
Jürgen GötzClem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Building #79, Brisbane, QLD 4072, Australia.
John R HodgesThe University of New South Wales and Neuroscience Research Australia, Margarete Ainsworth Building, Barker Street, Sydney, NSW 2031, Australia.
Matthew C KiernanBrain and Mind Research Institute, The University of Sydney, 94 Mallett Street, Camperdown, NSW 2050, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are related neurodegenerative disorders, which are characterized by a rapid decline in cognitive and motor functions, and short survival. Although the clinical and neuropathological characterization of these diseases has progressed--in part--through animal studies of pathogenetic mechanisms, the translation of findings from rodent models to clinical practice has generally not been successful. This article discusses the gap between preclinical animal studies in mice and clinical trials in patients with FTD or ALS. We outline how to better design preclinical studies, and present strategies to improve mouse models to overcome the translational shortfall. This new approach could help identify drugs that are more likely to achieve a therapeutic benefit for patients.

Indexed as

Drug Evaluation, PreclinicalTranslational Research, BiomedicalAmyotrophic Lateral SclerosisAnimalsDisease Models, AnimalFrontotemporal DementiaHumansMice

Identifiers

PMID25939274

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.