Evidence map›Paper›PMID 25939038›Full record

ReviewAnnual review of analytical chemistry (Palo Alto, Calif.)2015

Electrochemical Analysis of Neurotransmitters.

Elizabeth S Bucher, R Mark Wightman

Registry-linked trialAbstract readReview
In one paragraph

Review in Annual review of analytical chemistry (Palo Alto, Calif.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06853977 (Understanding the Role of Monoaminergic Neurotransmitters in Cognitive Functions Using Fast-cyclic Voltammetry in Patients With Neurological and Psychiatric Diseases Eligible for Neurosurgical Treatment), which is not on this map. Cited by 110 papers.

0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06853977 naactive not recruitingnot on this mapstarted 2025, after this paper: background citation

Understanding the Role of Monoaminergic Neurotransmitters in Cognitive Functions Using Fast-cyclic Voltammetry in Patients With Neurological and Psychiatric Diseases Eligible for Neurosurgical Treatment (COGAMINE)

TypeinterventionalSponsorCentre Hospitalier St AnneRan2025 to 2035Enrolled200ConditionsNeurological Diseases or Conditions, Psychiatric Diseases, Candidates for Deep Brain Stimulation, Candidates for Invasive S-EEGArmsCognitive tasks
3 · Its place in the literature

Who cites it

110 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Editorial: Carbon microelectrodes for neurochemical sensing.Frontiers in bioengineering and biotechnology · 2026
    Article
  5. A Poly(methacrolein-Nanomaterials (Basel, Switzerland) · 2025
    Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Surface-Roughened Graphene Oxide Microfibers Enhance Electrochemical Reversibility.Langmuir : the ACS journal of surfaces and colloids · 2024
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

50 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Elizabeth S BucherDepartment of Chemistry and Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599; email: rmw@unc.edu , ebucher@email.unc.edu.
R Mark Wightman

Funding

DYNAMICS OF IN VIVO DOPAMINE RELEASER01DA010900 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WIGHTMAN, ROBERT MARK · 1997 to 2017
$5.1M
ELECTROANALYSIS OF NEUROTRANSMITTERS AND MODULATORSR01NS015841 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WIGHTMAN, ROBERT MARK · 1985 to 2014
$4.3M
Electrochemical tools to measure local cerebral blood flow and metabolismR01DA032530 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WIGHTMAN, ROBERT MARK · 2012 to 2016
$1.8M
NIDA NIH HHS DA010900NIDA NIH HHS DA032530NIDA NIH HHS R01 DA010900NIDA NIH HHS R01 DA032530NINDS NIH HHS NS015841NINDS NIH HHS R01 NS015841
6 · The paper itself

Abstract

Chemical signaling through the release of neurotransmitters into the extracellular space is the primary means of communication between neurons. More than four decades ago, Ralph Adams and his colleagues realized the utility of electrochemical methods for the study of easily oxidizable neurotransmitters, such as dopamine, norepinephrine, and serotonin and their metabolites. Today, electrochemical techniques are frequently coupled to microelectrodes to enable spatially resolved recordings of rapid neurotransmitter dynamics in a variety of biological preparations spanning from single cells to the intact brain of behaving animals. In this review, we provide a basic overview of the principles underlying constant-potential amperometry and fast-scan cyclic voltammetry, the most commonly employed electrochemical techniques, and the general application of these methods to the study of neurotransmission. We thereafter discuss several recent developments in sensor design and experimental methodology that are challenging the current limitations defining the application of electrochemical methods to neurotransmitter measurements.

Indexed as

AnimalsBiosensing TechniquesElectrochemical TechniquesHumansNeurotransmitter AgentsNeurotransmitter Agentsamperometrybiosensorscarbon-fiber microelectrodescatecholaminesexocytosisvoltammetry

Identifiers

PMID25939038
PMCPMC4728736

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.