ArticleNature neuroscience2015
An astrocyte-dependent mechanism for neuronal rhythmogenesis.
Article in Nature neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
91 citing papers in PubMed, 1 synthesis or guideline pooled it.
- GFAP and S100B: What You Always Wanted to Know and Never Dared to Ask.Frontiers in neurology · 2022Pooled it
- Review
- Neural Control of Mastication: Ion-Channel Mechanisms in the Brainstem Central Pattern Generator.Brain sciences · 2026Review
- Brainstem Circuits for Rhythm Generation and Coordination of Orofacial Movements.Annual review of neuroscience · 2026Review
- The calcium-binding protein S100β regulates synaptic plasticity in the visual cortex.iScience · 2026Article
- Astrocyte Regulation of Spinal Circuit Function.Journal of neurochemistry · 2026Review
- Contribution of proprioceptors in the mesencephalic trigeminal nucleus and their surrounding astrocytes to acidic saline-induced chronic jaw muscle pain in rodents.Frontiers in cellular neuroscience · 2026Article
- Deletion of the calcium-binding protein S100β alters axon initial segment development in the visual cortex.Frontiers in cellular neuroscience · 2026Article
- Calcium Dynamics in Astrocyte-Neuron Communication from Intracellular to Extracellular Signaling.Cells · 2025Review
- Enteric glial S100B controls rhythmic colonic functions by regulating excitability and specificity in gut motor neurocircuits.The Journal of physiology · 2025Article
- Article
- Role of Ion Channels in Alzheimer's Disease Pathophysiology.The Journal of membrane biology · 2025Review
- Post-Stroke Rehabilitation: Neurophysiology Processes of Bilateral Movement Training and Interlimb Coupling-A Systematic Review.Journal of clinical medicine · 2025Review
- Astrocytes at the heart of sleep: from genes to network dynamics.Cellular and molecular life sciences : CMLS · 2025Review
- The Duality of Astrocyte Neuromodulation: Astrocytes Sense Neuromodulators and Are Neuromodulators.Journal of neurochemistry · 2025Review
- Astrocyte-induced firing in primary afferent axons.iScience · 2025Article
- Astrocyte-neuron crosstalk in neurodevelopmental disorders.Current opinion in neurobiology · 2024Review
- Rapid modulation of striatal cholinergic interneurons and dopamine release by satellite astrocytes.Nature communications · 2024Article
- Astrocyte allocation during brain development is controlled by Tcf4-mediated fate restriction.The EMBO journal · 2024Article
- Review
31 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Communication between neurons rests on their capacity to change their firing pattern to encode different messages. For several vital functions, such as respiration and mastication, neurons need to generate a rhythmic firing pattern. Here we show in the rat trigeminal sensori-motor circuit for mastication that this ability depends on regulation of the extracellular Ca(2+) concentration ([Ca(2+)]e) by astrocytes. In this circuit, astrocytes respond to sensory stimuli that induce neuronal rhythmic activity, and their blockade with a Ca(2+) chelator prevents neurons from generating a rhythmic bursting pattern. This ability is restored by adding S100β, an astrocytic Ca(2+)-binding protein, to the extracellular space, while application of an anti-S100β antibody prevents generation of rhythmic activity. These results indicate that astrocytes regulate a fundamental neuronal property: the capacity to change firing pattern. These findings may have broad implications for many other neural networks whose functions depend on the generation of rhythmic activity.
Indexed as
Identifiers
25938883What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.