ArticlePediatric research2015
Dietary aflatoxin-induced stunting in a novel rat model: evidence for toxin-induced liver injury and hepatic growth hormone resistance.
Article in Pediatric research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- An untargeted metabolomic analysis of acute AFB1 treatment in liver, breast, and lung cells.PloS one · 2025Article
- The Impact of Fermentation on Aflatoxin and Fumonisin Levels in Sorghum Kernels and Flour Used to Prepare Complementary Food in Kerio Valley, Kenya.Food science & nutrition · 2024Article
- Clover microgreen incorporation in diet-controlled diabetes and counteracted aflatoxicosis of rats.Food science & nutrition · 2023Article
- Diverse mycotoxin threats to safe food and feed cereals.Essays in biochemistry · 2023Review
- New Insights Into the Persistent Effects of Acute Exposure to AFBFrontiers in microbiology · 2022Article
- Determinants of knowledge about aflatoxin and fumonisin contamination in sorghum and postharvest practices among caregivers of children aged 6-59 months in Kerio Valley, Kenya.Food science & nutrition · 2021Article
- Aflatoxin Biosynthesis, Genetic Regulation, Toxicity, and Control Strategies: A Review.Journal of fungi (Basel, Switzerland) · 2021Review
- Estimating the health burden of aflatoxin attributable stunting among children in low income countries of Africa.Scientific reports · 2021Article
- Environment Changes, Aflatoxins, and Health Issues, a Review.International journal of environmental research and public health · 2020Review
- Risk assessment of aflatoxins in food.EFSA journal. European Food Safety Authority · 2020Article
- Aflatoxin MProbiotics and antimicrobial proteins · 2019Article
- Article
- Elucidating Adverse Nutritional Implications of Exposure to Endocrine-Disrupting Chemicals and Mycotoxins through Stable Isotope Techniques.Nutrients · 2018Review
- The Binding Efficiency and Interaction ofFrontiers in microbiology · 2018Article
- Effect of High Protein Diet and ProbioticBioMed research international · 2018Article
- Application of superabsorbent polymers (SAP) as desiccants to dry maize and reduce aflatoxin contamination.Journal of food science and technology · 2016Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundDespite a strong statistical correlation between dietary aflatoxin B1 (AFB1)-exposure and childhood stunting, the causal mechanism remains speculative. This issue is important because of emerging interest in reduction of human aflatoxin exposure to diminish the prevalence and complications of stunting. Pediatric liver diseases cause growth impairment, and AFB1 is hepatotoxic. Thus, liver injury might mediate AFB1-associated growth impairment. We have developed a rat model of dietary AFB1-induced stunting to investigate these questions.
methodsNewly-weaned rats were given AFB1-supplemented- or control-diets from age 3-9 wk, and then euthanized for serum- and tissue-collection. Food intake and weight were serially assessed, with tibial-length determined at the experimental endpoint. Serum AFB1-adducts, hepatic gene and protein expression, and liver injury markers were quantified using established methodologies.
resultsAFB1-albumin adducts correlated with dietary toxin contamination, but such contamination did not affect food consumption. AFB1-exposed animals exhibited dose-dependent wasting and stunting, liver pathology, and suppression of hepatic targets of growth hormone (GH) signaling, but did not display increased mortality.
conclusionThese data establish toxin-dependent liver injury and hepatic GH-resistance as candidate mechanisms by which AFB1-exposure causes growth impairment in this mammalian model. Interrogation of modifiers of stunting using this model could guide interventions in at-risk and affected children.
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