ArticlePloS one2015
Genetic diversity in oxytocin ligands and receptors in New World monkeys.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 47 citations in OpenAlex.
- Oxytocin modulates behavioral and physiological responses to a stressor in marmoset monkeys.Psychoneuroendocrinology · 2016Trial
- Oxytocin Variants Induce Cellular Signaling and Neurite Outgrowth in Human-Derived Neuron-like SH-SY5Y Cell Line.NeuroSci · 2026Article
- How Do Common Marmosets Maintain the Balance Between Response Execution and Action Inhibition?American journal of primatology · 2025Article
- Computational modeling of oxytocin-receptors interactions with the common marmoset Callithrix jacchus Pro8OT variant.Genetics and molecular biology · 2025Article
- Oxytocin has 'tend-and-defend' functionality in group conflict across social vertebrates.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Vasopressin, but not oxytocin, modulates responses to infant stimuli in marmosets providing care to dependent infants.Developmental psychobiology · 2020Article
- Comparison of the pharmacological profiles of arginine vasopressin and oxytocin analogs at marmoset, macaque, and human vasopressin 1a receptor.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2020Article
- Comparison of the pharmacologic profiles of arginine vasopressin and oxytocin analogs at marmoset, titi monkey, macaque, and human oxytocin receptors.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2020Article
- LeuScientific reports · 2019Article
- A Comparison of the Ability of LeuMolecular pharmacology · 2019Article
- Oxytocin structure and function in New World monkeys: from pharmacology to behavior.Integrative zoology · 2018Review
- Binding Characteristics of Two Oxytocin Variants and Vasopressin at Oxytocin Receptors from Four Primate Species with Different Social Behavior Patterns.The Journal of pharmacology and experimental therapeutics · 2018Article
- Oxytocin regulates reunion affiliation with a pairmate following social separation in marmosets.American journal of primatology · 2018Article
- Developmental trajectories and influences of environmental complexity on oxytocin receptor and vasopressin 1A receptor expression in male and female prairie voles.The Journal of comparative neurology · 2018Article
- Female dispersion and sex ratios interact in the evolution of mating behavior: a computational model.Scientific reports · 2018Article
- Functional New World monkey oxytocin forms elicit an altered signaling profile and promotes parental care in rats.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- The neurobiological causes and effects of alloparenting.Developmental neurobiology · 2017Review
- Initial investigation of three selective and potent small molecule oxytocin receptor PET ligands in New World monkeys.Bioorganic & medicinal chemistry letters · 2016Article
- Neuropeptide diversity and the regulation of social behavior in New World primates.Frontiers in neuroendocrinology · 2016Review
- Genes, dopamine pathways, and sociality in primates.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Oxytocin (OXT) is an important neurohypophyseal hormone that influences wide spectrum of reproductive and social processes. Eutherian mammals possess a highly conserved sequence of OXT (Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly). However, in this study, we sequenced the coding region for OXT in 22 species covering all New World monkeys (NWM) genera and clades, and characterize five OXT variants, including consensus mammalian Leu(8)-OXT, major variant Pro(8)-OXT, and three previously unreported variants: Ala(8)-OXT, Thr(8)-OXT, and Phe(2)-OXT. Pro(8)-OXT shows clear structural and physicochemical differences from Leu(8)-OXT. We report multiple predicted amino acid substitutions in the G protein-coupled OXT receptor (OXTR), especially in the critical N-terminus, which is crucial for OXT recognition and binding. Genera with same Pro(8)-OXT tend to cluster together on a phylogenetic tree based on OXTR sequence, and we demonstrate significant coevolution between OXT and OXTR. NWM species are characterized by high incidence of social monogamy, and we document an association between OXTR phylogeny and social monogamy. Our results demonstrate remarkable genetic diversity in the NWM OXT/OXTR system, which can provide a foundation for molecular, pharmacological, and behavioral studies of the role of OXT signaling in regulating complex social phenotypes.
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