ArticlePloS one2015
Molecular Cloning and Characterisation of Farnesyl Pyrophosphate Synthase from Tripterygium wilfordii.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 40 citations in OpenAlex.
- Integrated transcriptome and metabolome analysis reveal the sesquiterpenoid biosynthesis mechanism ofFrontiers in plant science · 2025Article
- Transcriptomic and physiological analysis of atractylodes chinensis in response to drought stress reveals the putative genes related to sesquiterpenoid biosynthesis.BMC plant biology · 2024Article
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- Functional characterization and transcriptional activity analysis ofFrontiers in plant science · 2023Article
- Genome-wide analysis of MYB family genes inPlant direct · 2022Article
- Probing the function of protein farnesyltransferase in Tripterygium wilfordii.Plant cell reports · 2019Article
- Positive Selection of Squalene Synthase in Cucurbitaceae Plants.International journal of genomics · 2019Article
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- A multifunctional oxidosqualene cyclase fromRSC advances · 2018Article
- Phylogeographic and phylogenetic analysis forEcology and evolution · 2017Article
- Molecular cloning and functional identification of a cDNA encoding 4-hydroxy-3-methylbut-2-enyl diphosphate reductase fromActa pharmaceutica Sinica. B · 2017Article
- Positive selection and functional divergence of farnesyl pyrophosphate synthase genes in plants.BMC molecular biology · 2017Article
- Functional characterization of NES and GES responsible for the biosynthesis of (E)-nerolidol and (E,E)-geranyllinalool in Tripterygium wilfordii.Scientific reports · 2017Article
- Genetic Transformation System for Woody PlantFrontiers in plant science · 2017Article
- Comparative proteomic analyses reveal the proteome response to short-term drought in Italian ryegrass (Lolium multiflorum).PloS one · 2017Article
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- Structure Conservation and Differential Expression of Farnesyl Diphosphate Synthase Genes in Euphorbiaceous Plants.International journal of molecular sciences · 2015Article
- Purification and Characterization of a Novel NAD(P)+-Farnesol Dehydrogenase from Polygonum minus Leaves.PloS one · 2015Article
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Authors and funding
9 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Farnesylpyrophosphate synthase (FPS) catalyzes the biosynthesis of farnesyl pyrophosphate (FPP), which is an important precursor of sesquiterpenoids such as artemisinin and wilfordine. In the present study, we report the molecular cloning and characterization of two full-length cDNAs encoding FPSs from Tripterygium wilfordii (TwFPSs). TwFPSs maintained their capability to synthesise FPP in vitro when purified as recombinant proteins from E. coli. Consistent with the endogenous role of FPS in FPP biosynthesis, TwFPSs were highly expressed in T. wilfordii roots, and were up-regulated upon methyl jasmonate (MeJA) treatment. The global gene expression profiles suggested that the TwFPSs might play an important regulatory role interpenoid biosynthesis in T. wilfordii, laying the groundwork for the future study of the synthetic biology of natural terpene products.
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