Evidence map›Paper›PMID 25938372›Full record

ArticleNature methods2015

MS-DIAL: data-independent MS/MS deconvolution for comprehensive metabolome analysis.

Hiroshi Tsugawa, Tomas Cajka, Tobias Kind, Yan Ma, Brendan Higgins, Kazutaka Ikeda, Mitsuhiro Kanazawa, Jean VanderGheynst, Oliver Fiehn, Masanori Arita

Abstract read
In one paragraph

Article in Nature methods, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1,509 papers.

0numbers the graph read from it
0cells of the map it votes in
1,509citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1,509 citing papers in PubMed.

  1. Trial
  2. Prebiotic Administration to Chronic Kidney Disease Patients Modifies Their Fecal Microbiome and Host Metabolism.Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation · 2026
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  7. The First Report of a Bang-Sensitive Strain inInternational journal of molecular sciences · 2026
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  9. Review
  10. Article
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  13. Integrative physiological and metabolomic study of Hirschfeldia incana under short- and medium-term lead (Pb) stress.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Article
  14. Article
  15. Article
  16. Article
  17. Article
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  19. Article
  20. Article

1,449 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hiroshi Tsugawa1] RIKEN Center for Sustainable Resource Science, Yokohama, Kanagawa, Japan. [2] Department of Biotechnology, Graduate School of Engineering, Osaka University, Suita, Osaka, Japan.
Tomas CajkaGenome Center, University of California Davis, Davis, California, USA.
Tobias KindGenome Center, University of California Davis, Davis, California, USA.
Yan MaGenome Center, University of California Davis, Davis, California, USA.
Brendan HigginsDepartment of Biological and Agricultural Engineering, University of California Davis, Davis, California, USA.
Kazutaka Ikeda1] RIKEN Center for Integrative Medical Sciences, Yokohama, Japan. [2] Japan Science and Technology Agency, Kawaguchi, Japan.
Mitsuhiro KanazawaReifycs Inc., Minato-ku, Tokyo, Japan.
Jean VanderGheynstDepartment of Biological and Agricultural Engineering, University of California Davis, Davis, California, USA.
Oliver Fiehn1] Genome Center, University of California Davis, Davis, California, USA. [2] Department of Biochemistry, Faculty of Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
Masanori Arita1] RIKEN Center for Sustainable Resource Science, Yokohama, Kanagawa, Japan. [2] National Institute of Genetics, Mishima, Japan.

Funding

West Coast Central Comprehensive Metabolomics Resource Core (WC3MRC)U24DK097154 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI FIEHN, OLIVER · 2012 to 2017
$9.9M
Functional Cardio-MetabolomicsP20HL113452 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI HAZEN, STANLEY L, TANG, WAI HONG WILSON · 2012 to 2016
$4.8M
Metabolomics: an accurate mass GC-DART AccuTOF mass spectrometer for routine idenS10RR031630 · NCRR · UNIVERSITY OF CALIFORNIA AT DAVIS · PI FIEHN, OLIVER · 2011 to 2011
$260k
NCRR NIH HHS S10 RR031630NHLBI NIH HHS P20 HL113452NIDDK NIH HHS U24 DK097154
6 · The paper itself

Abstract

Data-independent acquisition (DIA) in liquid chromatography (LC) coupled to tandem mass spectrometry (MS/MS) provides comprehensive untargeted acquisition of molecular data. We provide an open-source software pipeline, which we call MS-DIAL, for DIA-based identification and quantification of small molecules by mass spectral deconvolution. For a reversed-phase LC-MS/MS analysis of nine algal strains, MS-DIAL using an enriched LipidBlast library identified 1,023 lipid compounds, highlighting the chemotaxonomic relationships between the algal strains.

Indexed as

MetabolomeSoftwareChlorophytaChromatography, LiquidGene Expression Regulation, PlantLipid MetabolismLipidsSpecies SpecificityTandem Mass SpectrometryLipids

Identifiers

PMID25938372
PMCPMC4449330

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.