Evidence map›Paper›PMID 25938244›Full record

ArticlePsychology and aging2015

Genetic and environmental architecture of changes in episodic memory from middle to late middle age.

Matthew S Panizzon, Michael C Neale, Anna R Docherty, Carol E Franz, Kristen C Jacobson, Rosemary Toomey, Hong Xian, Terrie Vasilopoulos, Brinda K Rana, Ruth McKenzie and 2 more

Abstract read
In one paragraph

Article in Psychology and aging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Matthew S PanizzonDepartment of Psychiatry, Center for Behavioral Genomics, University of California, San Diego.
Michael C NealeVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University.
Anna R DochertyVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University.
Carol E FranzDepartment of Psychiatry and Center for Behavioral Genomics, University of California, San Diego.
Kristen C JacobsonDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago.
Rosemary ToomeyDepartment of Psychological and Brain Sciences, Boston University.
Hong XianDepartment of Biostatistics, St. Louis University.
Terrie VasilopoulosDepartment of Anesthesiology, University of Florida.
Brinda K RanaDepartment of Psychiatry, University of California, San Diego.
Ruth McKenzieDepartment of Psychological and Brain Sciences, Boston University.
Michael J LyonsDepartment of Psychological and Brain Sciences, Boston University.
William S KremenDepartment of Psychiatry, Center for Behavioral Genomics, University of California, San Diego.

Funding

The VETSA Longitudinal MRI Twin Study of AgingR01AG022381 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KREMEN, WILLIAM S. · 2003 to 2019
$22.3M
The VETSA Longitudinal Twin Study of Cognition and AgingR01AG018384 · NIA · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI LYONS, MICHAEL J. · 2002 to 2012
$9.8M
The VETSA longitudinal twin study of cognition and agingR01AG018386 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KREMEN, WILLIAM S. · 2002 to 2012
$9.7M
Research Training: Psychiatric &Statistical GeneticsT32MH020030 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI HERMINE H MAES, MICHAEL CHURTON NEALE · 1999 to 2026
$6.7M
The VETSA Longitudinal Twin Study of Cortisol and AgingR01AG022982 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KREMEN, WILLIAM S. · 2004 to 2007
$2.6M
Testosterone-Androgen Receptor Genetics: Role in Cognitive and Biological AgingK08AG047903 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PANIZZON, MATTHEW S · 2014 to 2017
$452k
NIA NIH HHS AG022381NIA NIH HHS AG022982NIA NIH HHS K08 AG047903NIA NIH HHS R01 AG018384NIA NIH HHS R01 AG018386NIA NIH HHS R01 AG022381NIA NIH HHS R01 AG022982NIMH NIH HHS T32 MH020030
6 · The paper itself

Abstract

Episodic memory is a complex construct at both the phenotypic and genetic level. Ample evidence supports age-related cognitive stability and change being accounted for by general and domain-specific factors. We hypothesized that general and specific factors would underlie change even within this single cognitive domain. We examined 6 measures from 3 episodic memory tests in a narrow age cohort at middle and late middle age. The factor structure was invariant across occasions. At both timepoints 2 of 3 test-specific factors (story recall, design recall) had significant genetic influences independent of the general memory factor. Phenotypic stability was moderate to high, and primarily accounted for by genetic influences, except for 1 test-specific factor (list learning). Mean change over time was nonsignificant for 1 test-level factor; 1 declined; 1 improved. The results highlight the phenotypic and genetic complexity of memory and memory change, and shed light on an understudied period of life.

Indexed as

EnvironmentMemory, EpisodicAgingCohort StudiesFemaleHumansLearningMaleMental RecallMiddle AgedNeuropsychological TestsPhenotypeTime Factors

Identifiers

PMID25938244
PMCPMC4451379

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.