Evidence map›Paper›PMID 25938135›Full record

ArticleAnnals of pediatrics & child health

The Role of Vitamin D in Pediatric Asthma.

Selene K Bantz, Zhou Zhu, Tao Zheng

Open access · greenAbstract read
In one paragraph

Article in Annals of pediatrics & child health. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Selene K BantzSection of Allergy and Clinical Immunology, Yale University School of Medicine New Haven, USA 06520.
Zhou ZhuSection of Allergy and Clinical Immunology, Yale University School of Medicine New Haven, USA 06520.
Tao ZhengSection of Allergy and Clinical Immunology, Yale University School of Medicine New Haven, USA 06520.
Yale University · US

Funding

Treating lung inflammation by targeting SiglecsP01HL107151 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI SCHNAAR, RONALD L · 2011 to 2017
$15.4M
EMERGING INFECTIOUS DISEASEST32AI007502 · NIAID · STANFORD UNIVERSITY · PI Prasanna Jagannathan, DAVID A. RELMAN · 1995 to 2026
$6.8M
ALLERGY AND IMMUNOLOGY TRAINING GRANTT32AI007174 · NIAID · YALE UNIVERSITY · PI ASKENASE, PHILIP WILLIAM · 1985 to 2015
$2.6M
IL-13 Atopic Dermatitis and Its Relationship with the Development of AsthmaR01AI075025 · NIAID · YALE UNIVERSITY · PI ZHENG, TAO · 2008 to 2012
$2.2M
SHP-1 Deficiency Induces Pulmonary Th2 InflammationR01HL079349 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI ZHU, ZHOU · 2006 to 2009
$1.6M
NHLBI NIH HHS P01 HL107151NHLBI NIH HHS R01 HL079349NIAID NIH HHS R01 AI075025NIAID NIH HHS T32 AI007174NIAID NIH HHS T32 AI007502
6 · The paper itself

Abstract

The detrimental effects of vitamin D deficiency in pediatrics have become increasingly apparent and extend beyond skeletal health. Unfortunately, vitamin D deficiency is highly prevalent in atopic pediatric patients, in whom it may disrupt the immune system and induce significant worsening of reactive airways. This review presents evidence that lung development and immune regulatory functions are vitamin D-dependent. We also review clinical studies that explore how vitamin D supplementation may prevent respiratory infections and help improve asthma control, and we elaborate how these effects may vary among populations. We reveal the strong need of screening measures for vitamin D deficiency in high risk pediatric populations, particularly African-Americans, Hispanic-Americans, and children with obesity. Finally, we emphasize that all children, especially those who are asthmatic, should be assessed to ensure adequate intake or supplementation with at least the minimum recommended doses of vitamin D. The simple intervention of vitamin D supplementation may provide significant clinical improvement in atopic disease, especially asthma.

Indexed as

allergen immunotherapyasthmaatopypediatricsVitamin D

Identifiers

PMID25938135
PMCPMC4415725
OpenAlexW2416040898

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.