ArticleInternational journal of ophthalmology2015
Bioinformatics analysis of potential essential genes that response to the high intraocular pressure on astrocyte due to glaucoma.
Article in International journal of ophthalmology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
aimTo study the gene expression response and predict the network in cell due to pressure effects on optic nerve injury of glaucoma.
methodsWe used glaucoma related microarray data in public database [Gene Expression Omnibus (GEO)] to explore the potential gene expression changes as well as correspondent biological process alterations due to increased pressure in astrocytes during glaucoma development.
resultsA total of six genes were identified to be related with pressure increasing. Through the annotation and network analysis, we found these genes might be involved in cell morphological remodeling, angiogenesis, mismatch repair.
conclusionIncreasing pressure in glaucoma on astrocytes might cause gene expression alterations, which might induce some cellular responses changes.
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