ArticleAntimicrobial resistance and infection control2015
Community acquired multi-drug resistant clinical isolates of Escherichia coli in a tertiary care center of Nepal.
Article in Antimicrobial resistance and infection control, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 83 citations in OpenAlex.
- Fluoroquinolone-Free Prophylaxis and Impact on Bacterial Infections, Resistance, and Survival in Allo-HSCT: 5-Year Follow-up of the BATMO Protocol (Best Anti-microbical Therapy Trapianto di Midollo Osseo).Open forum infectious diseases · 2026Article
- Monitoring for early prediction of gram-negative bacteremia using machine learning and hematological data in the emergency department.Communications medicine · 2025Article
- Virulence genes and phylogenetic analysis of antibiotic-resistantVeterinary world · 2025Article
- A nursing and midwifery training program in Kathmandu on antimicrobial resistance and stewardship and infection prevention and control: a qualitative and quantitative outcomes and process evaluation.Frontiers in public health · 2025Article
- Study of the Genomic Characterization of Antibiotic-ResistantIndian journal of microbiology · 2024Article
- Systematic Review and Meta-analysis on Extended-Spectrum β-lactamases ProducingMicrobiology insights · 2023Review
- Multi-drug Resistance, β-Lactamases Production, and Coexistence ofMicrobiology insights · 2023Article
- Effect of Nanoencapsulation on the Antimicrobial and Antibiofilm Activities of AlgerianNanomaterials (Basel, Switzerland) · 2022Article
- Characterization of virulence determinants and phylogenetic background of multiple and extensively drug resistant Escherichia coli isolated from different clinical sources in Egypt.Applied microbiology and biotechnology · 2022Article
- Characterization of the Lytic Phage Flora With a Broad Host Range Against Multidrug-ResistantFrontiers in veterinary science · 2022Article
- High prevalence of multiple antibiotic resistance in clinical E. coli isolates from Bangladesh and prediction of molecular resistance determinants using WGS of an XDR isolate.Scientific reports · 2021Article
- Three-Year Trend inChildren (Basel, Switzerland) · 2021Article
- Antibiotic resistance and detection of plasmid mediated colistin resistance mcr-1 gene among Escherichia coli and Klebsiella pneumoniae isolated from clinical samples.Gut pathogens · 2021Article
- Prevalence of multidrug-resistant and extended-spectrum beta-lactamase producing Gram-negative isolates from clinical samples in a tertiary care hospital of Nepal.Tropical medicine and health · 2021Article
- Detection ofDiseases (Basel, Switzerland) · 2021Article
- A high prevalence of multi-drug resistant Gram-negative bacilli in a Nepali tertiary care hospital and associated widespread distribution of Extended-Spectrum Beta-Lactamase (ESBL) and carbapenemase-encoding genes.Annals of clinical microbiology and antimicrobials · 2020Article
- Enhanced quantitative urine culture technique, a slight modification, in detecting under-diagnosed pediatric urinary tract infection.BMC research notes · 2020Article
- Plasmid-Mediated AmpC β-LactamaseInfection and drug resistance · 2020Article
- Extended-Spectrum β-Lactamase-ProducingInfectious diseases · 2020Article
- Extended-spectrum β-lactamase prevalence and virulence factor characterization of enterotoxigenicAntimicrobial resistance and infection control · 2018Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMulti-drug resistance (MDR) in Gram-negative organisms is an alarming problem in the world. MDR and extensively-drug resistance (XDR) is in increasing trend due to the production of different types of beta (β)-lactamases. Thus the aim of this study was to document the incidence of MDR and XDR in clinical isolates of Escherichia coli and also to find out the enzymatic mechanisms of β-lactam antibiotics resistance.
methodsTwo hundred clinical isolates of Escherichia coli (E. coli) identified by standard laboratory methods were studied. Antibiotic susceptibility profile was performed for all the isolates and the suspected isolates were phenotypically tested for the production of extended spectrum β-lactamase (ESBL), metallo β-lactamase (MBL) and AmpC β-lactamase (AmpC) by recommended methods.
resultsAround three-fourth (78%) of the total isolates were multi-drug resistant. ESBL, MBL and AmpC production was found in 24%, 15% and 9% of isolates respectively. Amikacin, chloramphenicol and colistin were found to be the most effective antibiotics.
conclusionsHigh percentage of MDR was observed. β-lactamase mediated resistance was also high. Thus, regular surveillance of drug resistance due to β-lactamases production and infection control policy are of utmost importance to minimize the spread of resistant strains.
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