ArticleIrish veterinary journal2015
Methylation of free-floating deoxyribonucleic acid fragments in the bronchoalveolar lavage fluid of dogs with chronic bronchitis exposed to environmental tobacco smoke.
Article in Irish veterinary journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 8 citations in OpenAlex.
- Long-term outcomes of dogs with W-shaped or traditional tracheal collapse treated with a continuous extraluminal tracheal prosthesis: A retrospective study.Veterinary surgery : VS · 2026Article
- Secondhand smoke and e-cigarette aerosol exposure in dogs and cats: A scoping review with implications for smoking cessation among pet owners.Tobacco prevention & cessation · 2026Review
- DNA methylation landscape of 16 canine somatic tissues by methylation-sensitive restriction enzyme-based next generation sequencing.Scientific reports · 2021Article
- An observational study of the role of indoor air pollution in pets with naturally acquired bronchial/lung disease.Veterinary medicine and science · 2020Article
- Genome-wide DNA methylation analysis in canine gastrointestinal lymphoma.The Journal of veterinary medical science · 2020Article
- Dynamic changes in DNA methylation patterns in canine lymphoma cell lines demonstrated by genome-wide quantitative DNA methylation analysis.Veterinary journal (London, England : 1997) · 2018Article
- Social Behavior of Pet Dogs Is Associated with Peripheral OXTR Methylation.Frontiers in psychology · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe etiology of canine chronic bronchitis (CB) is not completely understood, although exposure to environmental tobacco smoke (ETS) affects the airway inflammatory responses in some dogs with CB. The mechanism by which this occurs is unknown.
findingsWe investigated the concentrations and methylation rates of free-floating DNA fragments in bronchoalveolar lavage fluid (BALF) from dogs with chronic bronchitis. Based on serum cotinine levels, dogs with CB were divided into 2 groups: dogs that either had or had not been exposed to ETS. Our results demonstrated that the total nucleated cell and macrophage numbers increased in BALF of ETS-exposed dogs with CB. There were no significant differences in DNA concentrations and methylation rates in BALF between the 2 groups. However, 3 out of 8 dogs exposed to ETS had high DNA methylation rates in their BALF samples.
conclusionOur results suggest that ETS exposure leads to epigenetic modifications of cellular components in BALF in dogs diagnosed with CB.
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